Inhibition by Carbohydrates and Monoclonal Anticomplement Receptor Type 1, on Interactions between Senescent Human Red Blood Cells and Monocytic Macrophagic Cells
In order to be recognized and phagocytosed by Kupffer cells in the liver or by splenic or bone marrow macrophages, the human senescent red blood cells (Sen-RBC) must carry specific surface alterations that are recognized by the phagocytic cell. Previous works have shown that after injection into rabbits, neuraminidase-treated, sialic acid less autologous red blood cells (RBC) are promptly removed from the circulation; intact RBC previously incubated under the same conditions, but without neuraminidase, are removed from the circulation, after a significantly longer period (1–3). These results have suggested a role of sialic acid in the survival time of RBC in the circulation. However, treatment of RBC with sialidase did not result in the rapid clearance of young desialylated cells as might have been expected if loss of sialic acid were the primary signal for cell removal: the half-life of intact Sen-RBC was found to be significantly shorter than that of sialidase-treated young red blood cells (Y-RBC) with a similar sialic acid content (4).
KeywordsSialic Acid Complement Receptor Type Zymosan Particle Carbohydrate Derivative Mannosyl Residue
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