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Phagocytosis of Phenylhydrazine Oxidized and G-6-PD Deficient Red Blood Cells: The Role of Sugars and Cell-Bound Immunoglobulins

  • Sara Horn
  • Nava Bashan
  • Shimon Moses
  • Jacob Gopas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 307)

Abstract

Senescent or damaged red blood cells (RBCs) are selectively removed from the blood by macrophages in the spleen and liver (1). Changes observed in these cells involve various membranal modifications such as desialyzation (2–4), surface galactosyl exposure (5–7), degradation or configurai aggregation of band 3 (8-10) and changes in membrane phospholipid asymmetry (11,12). These modifications have been reported to be recognized by macrophages either directly (4–7,11,12), or indirectly, by binding of autoantibodies and complement components to the cells (2,8–10,13). Similar recognition mechanisms have been reported in some damaged RBCs such as in thalassemia and sickle cell anemia (10,11,14,15).

Keywords

Autologous Serum Additive Inhibitory Effect Membrane Phospholipid Asymmetry Autologous Antibody G6PD Deficient Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sara Horn
    • 1
  • Nava Bashan
    • 1
  • Shimon Moses
    • 1
  • Jacob Gopas
    • 1
  1. 1.Dept. of Biochemistry, Microbiology and Immunology Faculty of Health ScienceBen-Gurion UniversityBeer-ShevaIsrael

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