Bacterial Glycosidases and Degradation of Glycoconjugates in the Human Gut
When examining the molecular pathogenesis of gastrointestinal infections investigators should realize that colon contents contain a variety of hydrolases including proteases, phospholipases, and glycosidases. Their action on cell surface and surface-related structures in the intestine presumably influence both normal and pathological host-microbial associations. This is especially true of intralumenal glycosidases, since oligosaccharide moieties of cell membrane glycolipids and glycoproteins appear to have roles as molecular recognition sites for bacterial attachment (1) while those of mucin glycoproteins confer the viscoelastic gel properties to the overlying mucus layer (I. Carlstedt, this symposium) which is a habitat for some kinds of enteric bacteria (2).
KeywordsBlood Group Enteric Bacterium Oligosaccharide Chain Fecal Culture Fecal Extract
Abbreviations used in text
hog gastric mucin
N-Acetylneuraminic (sialic acid)
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