The Binding of Bacteria Carrying CFAs and Putative CFAs to Rabbit Intestinal Brush Border Membranes

  • Christine Wennerås
  • Jan Holmgren
  • Moyra M. McConnell
  • Ann-Mari Svennerholm
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 58)

Abstract

Enterotoxigenic Escherichia coli, ETEC, colonize the human intestine by means of fimbrial structures called colonization factor antigens, CFAs. On human ETEC strains three different types of CFAs have been described, i.e. the colonization factor antigens I, (CFA/I), CFA/II and CFA/IV. In addition a number of “new” putative colonization factor antigens have been identified, e.g. PCF0166, CS7, CS17 and CFA/III [M.M McConnell, this volume] although their prevalence and role in colonization have not been fully assessed.

Keywords

Diarrhea Macromolecule Glyco 

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References

  1. 1.
    C. Wennerås, J. Holmgren, and A-M Svennerholm. The binding of colonization factor antigens of enterotoxigenic Escherichia coli to intestinal cell membrane proteins. FEMS Microbiol. Lett. 66: 107 (1990).CrossRefGoogle Scholar
  2. 2.
    H.S. Orö, A-B Kolstö, C. Wennerås, and A-M Svennerholm. Identification of asialo-GM1 as a binding structure for Escherichia coli colonization factor antigens. FEMS Microbiol. Lett. (In press).Google Scholar
  3. 3.
    D.L. Hasty and W.A. Simpson. Effects of fibronectin and other salivary macromolecules on the adherence of Escherichia coli to buccal epithelial cells. Infect. Immun. 55:2103 (1987).PubMedGoogle Scholar
  4. 4.
    C. Åhrén, and A-M Svennerholm. Experimental enterotoxin-induced Escherichia coli diarrhoea and protection induced by previous infection with bacteria of the same adhesin or enterotoxin type. Infect. Immun. 50: 255 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Christine Wennerås
    • 1
  • Jan Holmgren
    • 1
  • Moyra M. McConnell
    • 2
  • Ann-Mari Svennerholm
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyGöteborgSweden
  2. 2.Central Public Health LaboratoryDivision of Enteric PathogensLondonUK

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