Expression of Type 1 Fimbriae by E.coli F18 in the Streptomycin-Treated Mouse Large Intestine
E. coli F18, isolated from the feces of a healthy human, is an excellent colonizer of the streptomycin-treated mouse large intestine. Adhesion of E. coli F18 to specific receptors present in cecal and colonic mucus was inhibited by D-mannose, suggesting that the E. coli F18 Type 1 fimbriae may mediate adhesion to intestinal mucosal components. Recently, we reported that E. coli F18 and E. coli F18 FimA, an isogenic strain unable to produce Type 1 fimbriae, colonized the streptomycin treated mouse large intestine, when fed to mice simultaneously. This result suggests that Type 1 fimbriae may not be expressed invivo. In the present study, we show that E. coli F18 does express Type 1 fimbriae invivo. Furthermore, our data suggest that Type 1 fimbriae may be a limiting colonization factor to a specific niche (site) in the large intestine.
KeywordsLarge Intestine Brush Border Membrane Specific Niche Isogenic Strain Distinct Niche
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