Immune Response to Vibrio cholerae Infection in Rabbits with Special Reference to Antibodies Against in vivo Specific Antigens
In Vibrio cholerae 01 bacteria, the causative agent of cholera, changes in the in vitro environment have been found to have marked influences both on the production of cholera toxin and of cell-surface associated structures, e.g. haemagglutinins, outer membrane proteins and a toxin-coregulated pilus (TCP)1,2. We have previously shown that the intestinal milieu provide an environment in which V. cholerae 01 of both El Tor and classical biotype expresses new surface antigens, that are not found after in vitro-growth3. We have also recently shown, by studying in vivo-grown bacteria, that both TCP and a putative adhesin on El Tor vibrios, i.e. the mannose-sensitive haemagglutinin (MSHA), are expressed by V. cholerae during infection4.
KeywordsAntibody Response Cholera Toxin Cholera Vibrio Pilus Colonization Classical Biotype
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- 4.G. Jonson, A-M. Svennerholm, and J. Holmgren, Expression of virulence factors by classical and El Tor Vibrio cholerae in vivo and in vitro. FEMS Ecology (1990).Google Scholar