The Pathogenic Mechanisms of Helicobacter pylori — A Short Overview
In recent years Helicobacter pylori (previously Campylobacter pylori)1 has become an established pathogen shown to cause the most common form of gastritis in humans (i.e. type B gastritis) and is able to infect human volunteers as well as monkeys and germfree piglets1–8. It has also been established that H. pylori is a major factor in developing stomach as well as duodenal ulcer disease in humans. Epidemiological studies have shown that H. pylori infections occur in early childhood with high incidence of atrophic gastritis predisposing to gastric cancer3. Since H. pylori cause such diverse entities as histological gastritis and peptic ulcers, it seems most likely that the disease mechanisms are both complex and include several virulence factors. Virulence properties on H. pylori known today allowing colonization of the gastric epithelium are summarized in Table 1.
KeywordsPeptic Ulcer Atrophic Gastritis Pylorus Strain Gastric Epithelium Duodenal Ulcer Disease
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