Structure and Properties of Rat Gastrointestinal Mucins

  • Ingemar Carlstedt
  • Stefan Elmquist
  • Ingela Ljusegren
  • Gunnar C. Hansson
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 58)


Mucus is a highly hydrated gel which covers the mucosal surfaces of the body and provides a protective barrier against the external environment. The major part (>95%) of mucus is water and the gel matrix is formed by large and complex glycoproteins referred to as the mucus glycoproteins or the mucins, which account for about 0.5–5% of the secretion. In addition, proteins such as secretory IgA, lysozyme, lactoferrin and proteinase inhibitors are often present in the gel.


Gastric Mucin Mucus Glycoprotein Neutral Oligosaccharide Intestinal Mucin Mucosal Scraping 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    I. Carlstedt and J.K. Sheehan, Structure and macromolecular properties of cervical mucus glycoproteins, in: Mucus and Related Topics, E. Chantler and N.A. Ratcliffe, eds., The Company of Biologists Ltd, Cambridge (1989).Google Scholar
  2. 2.
    S. Mårtensson, A. Lundblad, G.C. Hansson and I. Carlstedt, Mucins obtained from patients with enterocutaneous urinary diversions, Scand J Clin Lab Invest. 48:633 (1988).PubMedCrossRefGoogle Scholar
  3. 3.
    I. Carlstedt, H. Lindgren, J.K. Sheehan, U. Ulmsten and L. Wingerup, Isolation and characterization of human cervical-mucus glycoproteins, Biochem J. 211:13 (1983).PubMedGoogle Scholar
  4. 4.
    G.C. Hansson, J.K. Sheehan and I. Carlstedt, Only trace amounts of fatty acids are found in pure mucus glycoproteins, Arch Biochem Biophys. 266:197 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    D.J. Thornton, J.R. Davies, M. Kraayenbrink, P.S. Richardson, J.K. Sheehan and I. Carlstedt, Mucus glycoproteins from ’normal’ human tracheobronchial secretion, Biochem J. 265:179 (1990).PubMedGoogle Scholar
  6. 6.
    H. Karlsson, I. Carlstedt and G.C. Hansson, The use of gas chromatography and gas chromatography-mass spectrometry for the characterization of permethylated oligosaccharides with molecular mass up to 2300, Anal Biochem. 182:438 (1989).PubMedCrossRefGoogle Scholar
  7. 7.
    J. Dekker, W.M.O. Van Beurden-Lamers, A. Oprins and G.J. Strous, Isolation and structural analysis of rat gastric mucus glycoprotein suggests a homogeneous protein backbone, Biochem J. 260:717 (1990).Google Scholar
  8. 8.
    K.-A. Karlsson, Animal glycosphingolipids as membrane attachment sites for bacteria, Ann Rev Biochem. 58:309 (1989).PubMedCrossRefGoogle Scholar
  9. 9.
    S.U. Sajjan and J.F. Forstner, Role of the putative ’link’ glycopeptide of intestinal mucin in binding of piliated Escherichia coli serotype O157:H7 strain CL-49, Infect Immun. 58:868 (1990).PubMedGoogle Scholar
  10. 10.
    B.F. Smith and J.T. LaMont, Hydrophobic binding properties of bovine gallbladder mucin, J Biol Chem. 259:12170 (1984).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ingemar Carlstedt
    • 1
  • Stefan Elmquist
    • 1
  • Ingela Ljusegren
    • 1
  • Gunnar C. Hansson
    • 2
  1. 1.Department of Physiological Chemistry 2University of LundLundSweden
  2. 2.Department of Medical BiochemistryUniversity of GothenburgGothenburgSweden

Personalised recommendations