Structure and Function of Clostridium difficile Toxins

  • S. P. Borriello
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 58)


To understand the structure function relationship of a protein toxin it is essential to first have a clear understanding of the functional activities. For the purpose of this brief overview on the structure-function relationship of Clostridium difficile toxins A and B an attempt will be made to concentrate on known or proposed functions as opposed to effects. This can be best exemplified by comparing the haemagglutinating activity of toxin A which is mediated by binding to a specific tri-saccharide (a known function), to the ability of both toxins to cause cell rounding by disruption of the cell cytoskeleton (an effect exerted by unknown mechanisms and for which particular functions have not been identified). This brief overview will attempt to identify known functions of the toxin molecules, to highlight what is known of secondary structure and to comment on identified structure-function relationships.


Clostridium Difficile Diphtheria Toxin Rabbit Erythrocyte Native Toxin Denature Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • S. P. Borriello
    • 1
  1. 1.Microbial Pathogenicity Research GroupClinical Research CentreHarrow, MiddlesexUK

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