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Heat-Stable Enterotoxins Produced by Enteric Bacteria

  • Yoshifumi Takeda
  • Shinji Yamasaki
  • Toshiya Hirayama
  • Yasutsugu Shimonishi
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 58)

Abstract

Enterotoxigenic Escherichia coli produces two types of enterotoxin that cause diarrhea in humans and cattles. One is a high molecular weight heat-labile enterotoxin (LT) and the other is a low molecular weight heat-stable enterotoxin (ST). Two different kinds of ST have been described. One is STa or STI that is methanol soluble and active in suckling mice and piglets, but inactive in weaned pigs. The other is STb or STII that is methanol insoluble and active in weaned pigs, but inactive in suckling mice. At least two genetically distinct STa’s, that is STIa and STIb, have been reported. STIa and STIb also have been called STp and STh, respectively, because STIa and STIb were originally reported in E. coli isolated from pigs (and cows) and humans, respectively, although human isolates produce both STh and STp.

Keywords

Disulfide Bond Toxic Activity Enteric Bacterium Amino Acid Replacement Disulfide Bond Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Yoshifumi Takeda
    • 1
  • Shinji Yamasaki
    • 1
  • Toshiya Hirayama
    • 2
  • Yasutsugu Shimonishi
    • 3
  1. 1.Department of MicrobiologyFacutly of Medicine Kyoto UniversityKyotoJapan
  2. 2.The Institute of Medical ScienceThe University of TokyoTokyoJapan
  3. 3.Institute for Protein ResearchOsaka UniversityOsakaJapan

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