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Molecular Biology of Escherichia coli Type 1 Fimbriae

  • Per Klemm
  • Karen A. Krogfelt
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 58)

Abstract

Most strains of Escherichia coli are able to express type 1 fimbriae. These are thread-like surface organelles consisting of around 1000 subunits of a major structural component, the FimA protein, as well as a few percent minor components. Type 1 fimbriae mediate binding to D-mannose containing structures and thereby enable the bacteria to colonize various host tissues (1, 2). Inhibition of binding of type 1 fimbriated bacteria as well as purified type 1 fimbriae to various cell types has been extensively studied. In all cases it was found that D-mannose itself and most derivatives of this sugar were very potent inhibitors of type 1 fimbriae mediated adhesion, whereas all saccharides not containing D-mannose showed no inhibitory effect. It has been proposed that the biological role of type 1 fimbriae is to provide bacterial adhesion to mucus in the large intestine which is the natural habitat of E. coli. Furthermore, several lines of evidence point to a role of type 1 fimbriae as possible virulence factors in uropathogenic E. coli strains.

Keywords

Phase Switch Integration Host Factor HB101 Cell Export Machinery Fimbrial Adhesins 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Per Klemm
    • 1
  • Karen A. Krogfelt
    • 1
  1. 1.Department of MicrobiologyTechnical University of DenmarkLyngbyDenmark

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