Newly Characterized Putative Colonization Factors of Human Enterotoxigenic Escherichia coli
Enterotoxigenic Escherichia coli (ETEC) are an important cause of diarrhoeal disease in infants in developing countries and in travellers to these countries. These E.coli belong to a large number of different serotypes but have common pathogenic mechanisms namely the ability to adhere to the epithelial surface of the small intestine by means of colonization factors and to produce a heat stable (ST) or a heat labile (LT) enterotoxin, or both. Animal studies and volunteer experiments have shown that colonization factors and some toxins induce protective immunity and could be used to make vaccines1. However the effectiveness of a vaccine incorporating colonization factors will depend on the identification of these antigens on the majority of ETEC strains which cause diarrhoea in man.
KeywordsEscherichia Coli Diarrhoeal Disease Colonization Factor Volunteer Experiment Common Pathogenic Mechanism
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