Anesthetic Effects on Vascular Smooth Muscle
For many years it was generally believed that volatile anesthetic agents, with the exception of diethyl ether and cyclopropane, had a depressant effect on the vascular system. Because the physiological effects of anesthetic agents were measured in man and whole animal, the precise site or sites of action could not be determined. In 1962 Price and Price,1 using isolated tissue and standardized experimental conditions, reported that the effect of halothane was primarily at the adrenergic receptor on the vascular smooth muscle (VSM) cell. Other studies2 concluded that although the response to norepinephrine (NE) in VSM was depressed by halothane, antagonism between NE and halothane was difficult to explain in terms of classical pharmacological kinetics.
KeywordsVascular Smooth Muscle Coronary Blood Flow Inositol Phosphate Volatile Anesthetic Anesthetic Action
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