Contribution of the Known Subcellular Effects of Anesthetics to Their Negative Inotropic Effect in Intact Myocardium
Various anesthetics have been shown to affect virtually every step involved in myocardial excitation-contraction coupling. What is not known is the relative importance of these multiple effects to the overall negative inotropic response in intact myocardium. We have used isolated rabbit papillary muscles and left atrial muscles to evaluate the relative contribution of anesthetic effects on the transsarcolemmal Ca2+ influx, on the function of the sarcoplasmic reticulum, and on the response of the myofibril.
KeywordsSarcoplasmic Reticulum Control Force Muscle Length Negative Inotropic Effect Anesthetic Effect
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