The Endocytic Pathway for Human Immunodeficiency Virus Infection

  • C. David Pauza
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 300)


In this review, the pathway for infectious entry of HIV will be examined. Particular attention will be payed to analyzing the rates and efficiency of HIV binding, internalization, and uncoating. These kinetic parameters define the pathway for HIV penetration of T cells and monocytes and can be used to distinguish among the proposed routes for infectious entry of this virus. It is of practical significance to define the rate-limiting steps in the entry mechanism, as these reactions will be the most suitable targets for antiviral agents designed to interfere with HIV infection. These rate-limiting steps for infection of T cells and monocytes are compared in light of the kinetic analyses of virus entry discussed here.


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection U937 Cell Virus Entry Vesicular Stomatitis Virus 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • C. David Pauza
    • 1
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Wisconsin Medical SchoolMadisonUSA

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