Cells Infected by Human Immunodeficiency Virus in Vivo

  • Catherine Reynolds-Kohler
  • Clayton Wiley
  • Jay A. Nelson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 300)


The identification of human immunodeficiency virus (HIV) as the etiologic agent of AIDS has permitted the characterization of the virus by in vitro culture analysis. The ability to make HIV nucleic acid and antibody probes has also allowed us to determine the involvement of the virus in disease mechanisms in vivo. Classically, HIV is known to have a preferential tropism for cells that express the CD4 receptor1. These cells include T helper cells and many cells of the monocyte-macrophage lineage1-4. In addition to T cells and monocyte/macrophages, a variety of other cell types have been shown to support the growth of HIV including B-cells, Langerhans cells, follicular dendritic cells, glial cells and cells of the colon5-9. In order to understand the mechanism fo HIV infection it is important to identify the cell types naturally infected with the virus. The following chapter describes cell types that are infected in three distinct tissues. By utilizing in situ hybridization and immunocytochemistry techniques we have analyzed brain, bowel and placental tissue for the presence of HIV nucleic acid and antigen. In this chapter we applied these techniques to identify key cells naturally infected by HIV and to determine a possible mechanism for the transmission of the virus.


Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Multinucleated Giant Cell Enterochromaffin Cell Acquire Immune Deficiency Syndrome Patient 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Catherine Reynolds-Kohler
    • 1
    • 2
  • Clayton Wiley
    • 1
    • 2
  • Jay A. Nelson
    • 1
    • 2
  1. 1.Department of ImmunologyResearch Institute of Scripps ClinicLa JollaUSA
  2. 2.Department of PathologyUniversity of California San DiegoLa JollaUSA

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