Role of the Human Immunodeficiency Virus Type I Envelope Glycoprotein in Cytopathic Effect
The pathogenesis of acquired immune deficiency syndrome (AIDS) is characterized by a depletion of CD4-positive lymphocytes (for review, see Fauci, 1988). HIV-1 infection of CD4-positive lymphocytes and, to a lesser extent, monocyte/macrophages in tissue culture is accompanied by cytopathic effects (Popovic et al., 1984). The cytopathic effects follow a temporal course with the initial phase consisting of a period of formation of multinucleated giant cells or syncytia. This is followed by a phase of single cell lysis, which in turn is followed by a period of host cell resistance to cytopathic effect. In the latter phase, cells often continue to produce high titers of viruses that are cytopathic for fresh target cells, without undergoing obvious cytopathic effects.
KeywordsCarbohydrate Leukemia Carboxyl Disulfide Rosen
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