CD4 Envelope Interactions of HIV-1 and Related Human Retroviruses

  • James A. Hoxie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 300)


The externalized envelope molecules of all human and simian immunodeficiency viruses thus far described have been shown to bind to the CD4 molecule expressed on the surface of some T lymphocytes and monocytes. The interaction of the envelope with CD4 is important both early in infection where it mediates the initial adsorption of the virion to the cell surface, and later during viral replication where it may contribute to a variety of cytopathic effects as well as the down modulation of the CD4 molecule from the cell surface. We have evaluated the extent to which interactions between CD4 and the viral envelope vary among different members of the HIV-1, HIV-2 and SIV family of viruses, and have attempted to determine if these differences correlate with biological heterogeneity. We describe that remarkable differences do exist in the extent to which CD4-envelope binding occur and in the degree of CD4 modulation during viral replication. These differences may contribute both to the cytopathic potential of particular viruses, as well as in their ability to establish superinfection interference of related viral isolates.


Simian Immunodeficiency Virus Cytopathic Effect Reverse Transcriptase Activity Infected Cell Line Cell Free Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. S. McDougal, M. S. Kennedy, J. N. Sligh, S. P. Cort, S. M. Kennedy, A. C. Mawle, Science 231:382 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    M. Kowalski, J. Potz, L. Basiripour, T. Dorfman, W. C. Goh, E. Terwilliger, A. Dayton, C. Rosen, W. Haseltine, J. Sodroski, Science 237:1351 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    L. A. Lasky, G. Nakamura, J. H. Smith, C. Fennie, L. Shimosaki, E. Patzer, P. Berman, T. Gregory, D. J. Capon, Cell 50:975 (1987).PubMedCrossRefGoogle Scholar
  4. 4.
    D. H. Smith, R. A. Byrn, S. A. Marsters, T. Gregory, J. E. Groopman, D. J. Capon, Science 238:1704 (1987).PubMedCrossRefGoogle Scholar
  5. 5.
    P. J. Maddon, A. G. Dalgleish, J. S. McDougal, P. R. Clapham, R. A. Weiss, R. Axel, Cell 47:333 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    J. D. Lifson, G. R. Reyes, M. S. McGrath, B. S. Stein, E. G. Engleman, Science 232:1123 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    J. Sodroski, W. C. Goh, C. Rosen, K. Campbell, W. A. Haseltine, Nature (London) 322:470 (1986).CrossRefGoogle Scholar
  8. 8.
    A. DeRossi, G. Franchini, A. Aldovini, A. DelMistro, L. Chieco-Bianchi, R. C. Gallo, F. Wong-Staal, Proc. Natl. Acad. Sci. USA 4297 (1986).Google Scholar
  9. 9.
    R. Cheynier, M. Soulha, F. Loure, J. C. Vol, B. Réveil, R. C. Gallo, P. C. Sarin, D. Zagury, AIDS Res. and Human Retroviruses 4:43 (1988).CrossRefGoogle Scholar
  10. 10.
    J. A. Hoxie, J. D. Alpers, J. L. Rackowski, K. Huebner, B. S. Haggarty, A. J. Cedarbaum, J. C. Reed, Science 234:1123 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Stevenson, C. Meier, A. M. Mann, N. Chapman, A. Wasiak, Cell 53:483 (1988).PubMedCrossRefGoogle Scholar
  12. 12.
    Q. J. Sattentau, A. J. Dalgleish, R. A. Weiss, P. C. L Beverley, Science 234:1120 (1986).PubMedCrossRefGoogle Scholar
  13. 13.
    M. A. R. Yuille, M. Hugunin, P. John, L. Peer, L. V. Sacks, B. J. Poiesz, R. H. Tomar, and A. E. Silverstone, Jrl. Acquired Immune Deficiency Syndromes 1:131 (1988).Google Scholar
  14. 14.
    B. Guy, M. P. Kieny, Y. Riviere, C. Le Peuch, K. Dott, M. Girard, L. Montagnier, J-P. Lecocq, Nature 330: 266 (1988).CrossRefGoogle Scholar
  15. 15.
    A. G. Fisher, L. Ratner, H. Mitsuya, L M. Marselle, M. E. Harper, S. Broder, R. C. Gallo, F. Wong-Staal, Science 233: 655 (1986).PubMedCrossRefGoogle Scholar
  16. 16.
    P. J. Durda, B. Leece, A. Jenoski, H. Rabin, A. Fisher, and F. Wong-Staal, AIDS Research and Human Retroviruses 4:331 (1988).PubMedCrossRefGoogle Scholar
  17. 17.
    M. Guyader, M. Emmerman, P. Sonigo, F. Clavel, L. Montagnier, and M. Alizon, Nature 326:662 (1987).PubMedCrossRefGoogle Scholar
  18. 18.
    J. A. Hoxie, B. S. Haggarty, S. E. Bonser, J. L. Rackowski, H. Shan, and P. Kanki, J. Virol. 62:2557 (1988).PubMedGoogle Scholar
  19. 19.
    L I. Kong, S-W. Lee, J. C. Kappes, J. S. Parkin, D. Decker, J. A. Hoxie, B. H. Hahn, G. M. Shaw, Science 240:1525 (1988).PubMedCrossRefGoogle Scholar
  20. 20.
    L. A. Evans, J. Moreau, K. Odehouri, H. Legg, A. Barboza, C. Cheng-Mayer, J. A. Levy, Science 240:1522 (1988).PubMedCrossRefGoogle Scholar
  21. 21.
    K. C. Deen, J. S. McDougal, R. Inacker, G. Folena-Wasserman, J. Arthos, J. Rosenberg, P. J. Maddon, R. Axel, R. W. Sweet, Nature 82 (1988).Google Scholar
  22. 22.
    P. R. Clapham, J. N. Weber, D. Whitby, K. Mcintosh, A. G. Dalgleish, P. J. Maddon, K. C. Deen, R. W. Sweet, and R. A. Weiss, Nature 337 (1988).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James A. Hoxie
    • 1
  1. 1.Hematology-Oncology SectionHospital of the University of PennsylvaniaPhiladelphiaUSA

Personalised recommendations