Viral and Cellular Factors Influencing HIV Tropism
Studies of the human immunodeficiency virus (HIV) have indicated that virus-infected cells are most likely the major source of infection, and any approach that kills only the virus would not control HIV infection (1). Early observations suggested that the CD4+ T helper lymphocyte was the major cell type infected by HIV (2). Subsequent studies have demonstrated that a wide variety of cells coming from the hematopoietic and central nervous systems, the skin and the bowel are susceptible to HIV (3). Based on observations on a variety of HIV isolates it appears likely that, depending on the particular virus strain infecting the host, any human cell could be infected by HIV (4) (Table1). Its detection might be difficult in some cells in which viral replication takes place at a low level. Nevertheless, the presence of HIV could be revealed by Southern blot or polymerase chain reaction(PCR) techniques. Most importantly, if tissues in the body are infected by HIV, even if producing low levels of the virus, their function may be compromised.
KeywordsHuman Immunodeficiency Virus Peripheral Blood Mononuclear Cell Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Human Immunodeficiency Virus Replication
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