Pathologic Studies of Fetal Thyroid Development

  • Douglas R. Shanklin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 299)


Ordinarily the assignment of tissue change to the category of lesion or to variation is straightforward, depending on the character and extent of the change and its functional impact. The developmental process alters this relationship in large part because the effect is often in the future, sometimes the distant future. As such, what is “pathological” from the developmental point of view requires more understanding of the coordination of developing systems, the sequences for obtaining functional competency, and the effects of growth, maturation, and diseases in other organ systems. Specified injuries may have different effects on the time scale of development. Moreover, lesions in fetuses and newborns often have unusual features. It should be kept in mind that much of the final form, content, and location of many organs often depends on the removal of primordial structures which were earlier stages of those tissues. For the thyroid gland the process in question is that of folliculogenesis [Norris, 1914]. through the formation of a primordium later converted to follicles, a unique vertebrate structure.


Birth Weight Thyroid Stimulate Hormone Osteogenesis Imperfecta Congenital Hypothyroidism Original Magnification 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Douglas R. Shanklin
    • 1
  1. 1.Departments of Pathology and of Obstetrics and GynecologyUniversity of Tennessee, MemphisMemphisUSA

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