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Pathologic Studies of Fetal Thyroid Development

  • Douglas R. Shanklin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 299)

Abstract

Ordinarily the assignment of tissue change to the category of lesion or to variation is straightforward, depending on the character and extent of the change and its functional impact. The developmental process alters this relationship in large part because the effect is often in the future, sometimes the distant future. As such, what is “pathological” from the developmental point of view requires more understanding of the coordination of developing systems, the sequences for obtaining functional competency, and the effects of growth, maturation, and diseases in other organ systems. Specified injuries may have different effects on the time scale of development. Moreover, lesions in fetuses and newborns often have unusual features. It should be kept in mind that much of the final form, content, and location of many organs often depends on the removal of primordial structures which were earlier stages of those tissues. For the thyroid gland the process in question is that of folliculogenesis [Norris, 1914]. through the formation of a primordium later converted to follicles, a unique vertebrate structure.

Keywords

Birth Weight Thyroid Stimulate Hormone Osteogenesis Imperfecta Congenital Hypothyroidism Original Magnification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. Arey, L.B.: Developmental anatomy, 1956, Saunders, Philadelphia, p 231Google Scholar
  2. Chapman, E.M., G.W. Corner, D. Robinson and R.D. Evans: Collection of radioiodine by the human fetal thyroid. J.Clin.Endo. 8: 717–720, 1948CrossRefGoogle Scholar
  3. Chopra, I.J., D.H. Solomon, G.W. Hepner and A.A. Morgenstein: Misleadingly low free thyroxine index and usefulness of reverse triiodothyonine measurement in nonthyroidal illnesses. Ann.Int.Med. 90: 905–912, 1979PubMedGoogle Scholar
  4. Copp, D.H.: Calcitonin and parathyroid hormone. Ann.Rev.Pharmacol. 9: 327–344, 1969PubMedCrossRefGoogle Scholar
  5. Copp, D.H., D.W. Cockcroft and J. Kuel: Calcitonin from ultimobranchial glands of dogfish and chickens. Science 158: 924–925, 1967PubMedCrossRefGoogle Scholar
  6. de Vries, J.I.P., G.H.A. Visser and H.F.R. Prechtl: The-emergence of fetal behaviour. I. Qualitative aspects. Early Hum.Develop. 7: 301–322, 1982CrossRefGoogle Scholar
  7. Dorovini-Zis, K. and C.L. Dolman: Gestational development of brain. Arch.Pathol. 101: 192–195, 1977Google Scholar
  8. Dunn, T.B.: Ciliated cells of the thyroid of the mouse. J.Nat.Cancer Inst. 4: 555–557, 1944Google Scholar
  9. Fisher, D.A., C.J. Hobel, R. Garza and C.A. Pierce: Thyroid function in the preterm fetus. Pediatrics 46: 208–216, 1970PubMedGoogle Scholar
  10. Fisher, D.A. and A.H. Klein: Thyroid development and disorders of thyroid function in the newborn. New Eng.J.Med. 304: 702–712, 1981PubMedCrossRefGoogle Scholar
  11. Fisher, D.A., H. Lehman and C. Lackey: Placental transport of thyroxine. J.Clin.Endocr. 24: 393–400, 1964PubMedCrossRefGoogle Scholar
  12. Gorbman. A.: Functional and morphological properties in the thyroid gland, ultimobranchial body, and persisting ductus pharyngiobranchialis IV of an adult mouse. Anat.Rec. 98:93–101, 1947(a)Google Scholar
  13. Gorbman, A.: Thyroidal and vascular changes in mice following chronic treatment with goitrogens and carcinogens. Cancer Res. 7:746–758, 1947(b)Google Scholar
  14. Gorbman, A.: Tumorous growths in the pituitary and trachea following radiotoxic dosages of I131. Proc.Soc.Exp.Biol.Med. 71: 237–240, 1949PubMedGoogle Scholar
  15. Gray, H.: Anatole, of the human body, 25th ed., C.M. Goss, ed., 1948, Lea & Febiger, Philadelphia, pp. 1327–1329Google Scholar
  16. Hodges, R.E., T.C. Evans, J.T. Bradbury and W.C. Keettel: The accumulation of radioactive iodine by human fetal thyroids. J.Clin.Endo.Metab. 15: 661–667, 1955CrossRefGoogle Scholar
  17. Hulse, A.: Congenital hypothyroidism and neurological development. J.Child. Psvchol.Psvchiat. 24: 629–635, 1983CrossRefGoogle Scholar
  18. Loewenstein, J.E., and S.H. Wollman: Mechanisms for abnormally slow release of some thyroid radioiodine; an autoradiographic study. Endocrinology 87: 143–150, 1970PubMedCrossRefGoogle Scholar
  19. Mandel, S.J., P.R. Larsen, E.W. Seely and G.A. Brent: Increased need for thyroxine during pregnancy in women with primary hypothyroidism. New Eng.J.Med. 323: 91–96, 1990PubMedCrossRefGoogle Scholar
  20. Marin-Padilla, M.: Prenatal and early postnatal ontogenesis of the human motor cortex: a golgi study. I. The sequential development of the cortical layers. Brain Res. 23: 167–183, 1970PubMedCrossRefGoogle Scholar
  21. Morada, A.O.: Postmortem pulmonary edema; differential susceptibility in newborn and adult rabbits. Arch.Pathol. 85: 468–474, 1968PubMedGoogle Scholar
  22. Neve, P., and S.H. Wollman: Fine structure of a fifth type of epithelial cell in the thyroid gland of the C3H mouse. Anat.Rec. 172: 37–43, 1972PubMedCrossRefGoogle Scholar
  23. Norris, E.H.: The morphogenesis of the follicles in the human thyroid gland. Amer.J.Anat. 20: 411–448, 1916CrossRefGoogle Scholar
  24. Pantic, V.R.: The cytophysiology of thyroid cells. Int.Rev. Cytol. 38: 153–243, 1974PubMedCrossRefGoogle Scholar
  25. Porreco, R.P. and C.A. Bloch: Fetal blood sampling in the management of intrauterine thyrotoxicosis. Obstet.Gynec. 76: 509–512, 1990PubMedGoogle Scholar
  26. Potter, E.L.: Pathology of the fetus and the newborn, 1952, Year Book Publishers, Chicago, p. 13Google Scholar
  27. Ruiz de Ona, C., M. J. Obregon, F. Escobar del Rey, and G. Morreale de Escobar: Developmental changes in rat brain 5’-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyrodism and maternal thyroid hormones. Pediat.Res. 24: 588–594, 1988Google Scholar
  28. Sehe, C.T.: Observations on the ultimobranchial gland in small wild and laboratory mammals, with special reference to the histochemical localization of polysaccharides. J.Morph. 120: 425–441, 1966CrossRefGoogle Scholar
  29. Shanklin, D.R.: The influence of fixation on the histologic features of hyaline membrane disease. Amer.J.Path. 44: 823–837, 1964PubMedGoogle Scholar
  30. Shepard, T.H., H.J. Andersen and H. Andersen: The human fetal thyroid. I. Its weight in relation to body weight, crown-rump length, foot length and estimated gestational age. Anat.Rec. 148:123–128, 1964(a)Google Scholar
  31. Shepard, T.H., H. Andersen and H.J. Andersen: Histochemical studies of the human fetal thyroid during the first half of fetal life. Anat.Rec. 149:363–379, 1964 (b)Google Scholar
  32. Sterling, K.: Thyroid hormone action at the cell level. New Eng. J.Med. 300: 117–123, 173–177, 1979Google Scholar
  33. Streeter, G.L.: Weight, sitting height, head size, foot length and menstrual age of human embryos. Carnegie Inst.• Wash. Pub. 274, Contributions to Embryology (No. 55 ) 11: 143–170, 1920Google Scholar
  34. Streeter, G.L., C.H. Heuser, and G.W. Corner: Developmental horizons in human embryos. Contributions to Embryology (No. 230) Reprint vol. 115: 166–186, 1951Google Scholar
  35. Thorpe-Beeston, J.G., K.H. Nicolaides, C.V. Felton, J. Butler, and A.M. McGregor: Maturation of the secretion of thyroid hormone and thyroid stimulating hormone in the fetus. New Enc;.J.Med. 324: 532–536, 1991CrossRefGoogle Scholar
  36. Uhrmann, S., K.H. Marks, M.J. Maisels, Z. Friedman, F. Murray, H.E. Kulin, M. Kaplan and R. Utiger: Thyroid function in the preterm infant: a longitudinal assessment. J.Pediat. 92: 968–973, 1978PubMedCrossRefGoogle Scholar
  37. Vulsma, T., P.H. Gons and J.J.N. de Vijider: Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to total organification defect or thyroid agenesis. New Eng.J_.Med. 321: 13–16. 1989PubMedCrossRefGoogle Scholar
  38. Weiner, C.P.. Cordocentesis. O stet.Gynecol. Clin.N.Amer. 15: 283–301, 1988Google Scholar
  39. Weiss, R.E., S. Balzano, N.H. Scherberg and S. Refetoff: Neonatal detection of generalized resistance to thyroid hormone. J.A.M.A. 264: 2245–2250, 1990PubMedCrossRefGoogle Scholar
  40. Wenstrom, K.D., C.P. Weiner. R.A. Williamson and S.S. Grant: Prenatal diagnosis of fetal hyperthyroidism using funipu.ncture.. Obstet.Gynec. 76: 513–517, 1990PubMedGoogle Scholar
  41. Wetzel, S.K. and S.H. Wollman: The fine structure of “foamy” follicles in thyroid glands of C3H mice. J.Aprl. Physics 37: 3932. 1966 (abstract)Google Scholar
  42. Wetzel, B.K. and S.H. Wollman: Fine structure of a second kind of thyroid follicle in the C3H mouse. Endocrinol. 84: 563–578, 1969CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Douglas R. Shanklin
    • 1
  1. 1.Departments of Pathology and of Obstetrics and GynecologyUniversity of Tennessee, MemphisMemphisUSA

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