Use of TRH in the Fetus to Advance Lung Maturity

  • William F. O’Brien
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 299)


Respiratory distress syndrome (RDS) secondary to prematurity is a leading cause of perinatal mortality. The incidence of RDS increases as the gestational age at birth declines and occurs in approximately two thirds of infants born at 29–30 weeks gestational age (1). The functional immaturity of the fetal lung is both anatomic and biochemical. The most obvious abnormality is insufficient production of surfactant by the Type II alveolar cells. Composed of proteins and phospholipids and packaged in granules secreted by the alveolar lining cells, surfactant lines the air-tissue interface of the alveoli and decreases surface tension. This decrease in surface tension allows the alveoli to remain expanded in the absence of continuous airway pressure.


Thyroid Hormone Respiratory Distress Syndrome Fetal Lung Lung Maturation Combine Therapy Group 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • William F. O’Brien
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of South Florida College of MedicineTampaUSA

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