Huntington’s Disease

  • James F. Gusella
Part of the Advances in Human Genetics book series (AHUG, volume 20)


Huntington’s disease (HD) is an autosomal dominant disorder characterized by onset in adult life of progressive involuntary choreiform movements, and dementia (1). Though others had previously recognized the disorder, it only received widespread attention after a comprehensive description was published by George Huntington in 1872 (2). Huntington, a physician on Long Island, not only provided an excellent clinical summary of the movement disorder, but, because his patients in East Hampton were the progeny of similarly affected individuals previously treated by his father and grandfather, he also noted the inherited nature of the disease. For some of these families, the disease has been traced to ancestors who immigrated from Bures, England, landing in New England in 1649 (3,4).


Disease Gene Huntington Disease Candidate Region Somatic Cell Hybrid Crossover Event 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James F. Gusella
    • 1
    • 2
  1. 1.Department of GeneticsHarvard Medical SchoolCambridgeUSA
  2. 2.Molecular Neurogenetics LaboratoryMassachusetts General HospitalCharlestownUSA

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