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Huntington’s Disease

  • James F. Gusella
Part of the Advances in Human Genetics book series (AHUG, volume 20)

Abstract

Huntington’s disease (HD) is an autosomal dominant disorder characterized by onset in adult life of progressive involuntary choreiform movements, and dementia (1). Though others had previously recognized the disorder, it only received widespread attention after a comprehensive description was published by George Huntington in 1872 (2). Huntington, a physician on Long Island, not only provided an excellent clinical summary of the movement disorder, but, because his patients in East Hampton were the progeny of similarly affected individuals previously treated by his father and grandfather, he also noted the inherited nature of the disease. For some of these families, the disease has been traced to ancestors who immigrated from Bures, England, landing in New England in 1649 (3,4).

Keywords

Disease Gene Huntington Disease Candidate Region Somatic Cell Hybrid Crossover Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James F. Gusella
    • 1
    • 2
  1. 1.Department of GeneticsHarvard Medical SchoolCambridgeUSA
  2. 2.Molecular Neurogenetics LaboratoryMassachusetts General HospitalCharlestownUSA

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