Cerebrospinal Fluid Quinolinic Acid Concentrations are Increased in Acquired Immune Deficiency Syndrome
Infection of man with the human immunodeficiency virus (HIV) is associated with a variety of pathological consequences including involvement of the central nervous system. In addition to brain opportunistic conditions that occur in patients with the acquired immune deficiency syndrome (AIDS), a profile of neurologic dysfunctions has been described known as the AIDS dementia complex (ADC; Navia et al., 1986a,b; Price et al., 1988). At autopsy, diffuse pallor in the white matter, perivascular infiltrates of lymphocytes and macrophages, as well as loss of cortical neurons, have been described (Koenig et al., 1986; Navia et al., 1986a,b). Microglial nodules are found predominantly in cerebral cortex and basal ganglia and may be associated with cytomegalovirus infection. Koenig et al. (1986) have identified HIV in the brain in mononucleated and multinucleated macrophages.
KeywordsHuman Immunodeficiency Virus Acquire Immune Deficiency Syndrome Quinolinic Acid Acquire Immune Deficiency Syndrome Patient Opportunistic Condition
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- Heyes, M.P., and Markey, S.P., 1988a, Quantification of quinolinic acid in rat brain, whole blood and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations, Anal. Biochem., 174: 349–359.PubMedCrossRefGoogle Scholar
- Koenig, S., Gendelman, E., Orenstein, J.M., Dal Canto, M.C., Pezeshkpour, G.H. Yungbluth, M., Janotta, F., Aksamit, A., Martin, M.A., and Fauci, A.S., 1986, Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy, Science, 233: 1089–1093.PubMedCrossRefGoogle Scholar
- Takikawa, O., Yoshida, R., Kido, R., and Hayaishi, O., 1986, Tryptophan degradation in mice initiated by indoleamine-2, 3-dioxygenase, J. Biol. Chem., 261: 3648–3653.Google Scholar