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Cerebrospinal Fluid Quinolinic Acid Concentrations are Increased in Acquired Immune Deficiency Syndrome

  • M. P. Heyes
  • B. Brew
  • A. Martin
  • S. P. Markey
  • R. W. Price
  • R. B. Bhalla
  • A. Salazar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Infection of man with the human immunodeficiency virus (HIV) is associated with a variety of pathological consequences including involvement of the central nervous system. In addition to brain opportunistic conditions that occur in patients with the acquired immune deficiency syndrome (AIDS), a profile of neurologic dysfunctions has been described known as the AIDS dementia complex (ADC; Navia et al., 1986a,b; Price et al., 1988). At autopsy, diffuse pallor in the white matter, perivascular infiltrates of lymphocytes and macrophages, as well as loss of cortical neurons, have been described (Koenig et al., 1986; Navia et al., 1986a,b). Microglial nodules are found predominantly in cerebral cortex and basal ganglia and may be associated with cytomegalovirus infection. Koenig et al. (1986) have identified HIV in the brain in mononucleated and multinucleated macrophages.

Keywords

Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Quinolinic Acid Acquire Immune Deficiency Syndrome Patient Opportunistic Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. P. Heyes
    • 1
  • B. Brew
    • 2
  • A. Martin
    • 3
  • S. P. Markey
    • 1
  • R. W. Price
    • 2
  • R. B. Bhalla
  • A. Salazar
    • 3
  1. 1.Laboratory of Clinical Science NIMHSection on Analytical BiochemistryBethesdaUSA
  2. 2.Department of NeurologyMemorial Sloan-Kettering Memorial Cancer CenterNew YorkUSA
  3. 3.Walter Reed Army Medical CenterWashingtonUSA

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