Effects of Profound Insulin-Induced Hypoglycemia on Quinolinic Acid in Hippocampus and Plasma
Profound insulin-induced hypoglycemia is associated with neurodegenera-tion which resembles lesions produced by administration of exogenous excito-toxins (Auer, 1986). Neuronal lesions in hypoglycemia begin within minutes of the hypoglycemie insult and are attenuated by local application of N-methyl-D-aspartate (NMDA) receptor antagonists (Wieloch 1985; Simon et al., 1986).
KeywordsNMDA Receptor Quinolinic Acid Pyruvate Carboxylase Anthranilic Acid Cinic Acid
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