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Effects of Profound Insulin-Induced Hypoglycemia on Quinolinic Acid in Hippocampus and Plasma

  • M. P. Heyes
  • M. Papagapiou
  • C. Leonard
  • S. P. Markey
  • R. N. Auer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Profound insulin-induced hypoglycemia is associated with neurodegenera-tion which resembles lesions produced by administration of exogenous excito-toxins (Auer, 1986). Neuronal lesions in hypoglycemia begin within minutes of the hypoglycemie insult and are attenuated by local application of N-methyl-D-aspartate (NMDA) receptor antagonists (Wieloch 1985; Simon et al., 1986).

Keywords

NMDA Receptor Quinolinic Acid Pyruvate Carboxylase Anthranilic Acid Cinic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. P. Heyes
    • 1
    • 2
  • M. Papagapiou
    • 3
  • C. Leonard
    • 3
  • S. P. Markey
    • 2
  • R. N. Auer
    • 3
  1. 1.Laboratory of Clinical Science National Institute of Mental HealthSection on Analytical BiochemistryBethesdaUSA
  2. 2.Laboratory of NeurophysiologyNational Institute of Mental HealthBethesdaUSA
  3. 3.Neuroscience Research GroupUniversity of CalgaryCalgaryCanada

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