Tryptophan and its Metabolites in a Family with Hartnup Disease

  • D. D. Milovanović
  • L. Milovanović
  • B. Stanković
  • D. Radulović
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


A study dedicated to research of tryptophan and its metabolites in urine of Hartnup disease was published 30 years ago (Milne et al., 1960). The present paper pertains to the investigation of L-tryptophan (TRY), kynurenine (KYN), xanthurenic acid (XA), 5-hydroxyindoleacetic acid (5-HIAA) and indoxyl sulfate (IS) in plasma and urine of a four member family, with one symptomatic and one asymptomatic patient with Hartnup disease, prior to and after a TRY load. In parallel, one healthy subject was studied.


Paper Chromatography Cerebellar Ataxia Indoxyl Sulfate Xanthurenic Acid Renal Reabsorption 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • D. D. Milovanović
    • 1
  • L. Milovanović
    • 2
  • B. Stanković
    • 3
  • D. Radulović
    • 4
  1. 1.Clinic for Neurology and Psychiatry for Children and Young PeopleBelgradeSerbia
  2. 2.Laboratory for Drug ControlBelgradeSerbia
  3. 3.Institute of Analytical Chemistry Faculty of PharmacyUniversity of BelgradeSerbia
  4. 4.Institute of Pharmaceutical Chemistry Faculty of PharmacyUniversity of BelgradeSerbia

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