Tryptophan and its Metabolites in a Family with Hartnup Disease
A study dedicated to research of tryptophan and its metabolites in urine of Hartnup disease was published 30 years ago (Milne et al., 1960). The present paper pertains to the investigation of L-tryptophan (TRY), kynurenine (KYN), xanthurenic acid (XA), 5-hydroxyindoleacetic acid (5-HIAA) and indoxyl sulfate (IS) in plasma and urine of a four member family, with one symptomatic and one asymptomatic patient with Hartnup disease, prior to and after a TRY load. In parallel, one healthy subject was studied.
KeywordsPaper Chromatography Cerebellar Ataxia Indoxyl Sulfate Xanthurenic Acid Renal Reabsorption
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- Mortreuil, M., and Khouvine, Y., 1954, Dosage des acides amines par les complexes colorés dicetohydrindylidene-hydrindamine-sels de cadmium, Bull. Ste. Chim. Biol., 36: 425–428.Google Scholar
- Shih, V.E., Bixby, E.M., Alpers, D.H., Bartsocas, C.S., and Thier, S.O., 1971, Studies of intestinal transport defect in Hartnup disease, Gastro-enterology, 61: 445–453.Google Scholar