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Kynurenine and Mesangial-Proliferative Glomerulonephritis

  • V. Rudzite
  • V. Gromm
  • A. Martinsons
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

The increased kynurenine and xanthurenic acid excretion in urine observed in calcium oxalate urolithiasis is related to the decreased activity of kynureninase (Grimm et al., 1986), i.e. a pyridoxal-5-phosphate (P-5-P)-dependent enzyme. The present work reports on relationships between kynurenine accumulation in blood serum and renal cell failure studied by analyzing kidney biopsies and histological sections in cases with experimentally induced P-5-P deficiency in rats.

Keywords

Blood Serum Apical Part Calcium Oxalate Dependent Enzyme Proliferative Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Grimm, U., Steinhäuser, I., Wulf, K., Knapp, A., and Zschiesche, M., 1987, Tryptophan metabolic studies in calcium oxalate urolithiasis, in: “Progress in Tryptophan and Serotonin Research 1986”, Bender, D.Ä., Joseph, M.H., Kochen, W., and Steinhart, H., eds., de Gruyter, Berlin, pp. 295–300.Google Scholar
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  3. Serfontein, W.J., Ubbink, J.B., De Viller, L.S., Rapley, C.H., and Becker, P.J., 1985, Plasma pyridoxal-5-phosphate level as risk index for coronary artery disease, Atherosclerosis, 55: 357–361.PubMedCrossRefGoogle Scholar
  4. Weber, E., 1957, “Grundriss der biologischen Statistik für Naturwissenschaftler, Landwirte und Mediziner”, VEB Gustav Fischer Verlag, Jena.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • V. Rudzite
    • 1
  • V. Gromm
    • 1
  • A. Martinsons
    • 1
  1. 1.Latvian Research Institute of CardiologyRigaUSSR

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