Efficiency of Exogenous Quinolinic Acid, A Metabolite of Tryptophan, as a Niacin Precursor in Rats

  • K. Shibata
  • K. Murata
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


It is generally known that protein nutrition, especially tryptophan metabolites, niacin intake and amino acid balance are important for the prevention of pellagra. The pathway from tryptophan to NAD via kynurenine, 3-hydroxyanthranilic acid and quinolinic acid (QA) has been shown to be particularly important from the nutritional standpoint (Krehl et al., 1946; Henderson and Hirsch, 1949; Nishizuka and Hayaishi, 1963).


Nicotinic Acid Basal Diet Quinolinic Acid Pyridine Nucleotide Amino Acid Balance 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • K. Shibata
    • 1
  • K. Murata
    • 2
  1. 1.Department of Food Science and NutritionTeikoku Women’s UniversityMoriguchi Osaka 570Japan
  2. 2.Research Institute for EducationTeikoku GakuenMoriguchi Osaka 570Japan

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