Abstract
For some years, we have been interested in the role of neutral amino acids in the development and maintenance of hypertension. Our initial studies with tyrosine suggested that chronic dietary treatment with this essential amino acid could provide modest protection against the development of renal hypertension in rats (Lockley et al., 1985). However, it was considerably less effective in protecting against the development of deoxycorticosterone (DOCA)-induced hypertension (Henley et al., 1986).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fregly, M.J., and Fater, D.C., 1986, Prevention of DOCA-induced hypertension by chronic treatment with tryptophan, Clin. Exp. Pharmacol. Physiol., 13: 767–776.
Fregly, M.J., Lockley, O.E., and Cade, J.R., 1988, Effect of chronic dietary treatment with L-tryptophan on the development of renal hypertension in rats, Pharmacology, 36: 91–100.
Fregly, M.J., Lockley, O.E., and Sumners, C., 1987a, Chronic treatment with L-5-hydroxytryptophan prevents the development of DOCA-salt-induced hypertension in rats, J. Hypertens., 5: 621–628.
Fregly, M.J., Lockley, O.E., van der Voort, J., Sumners C., and Henley, W.N., 1987b, Chronic dietary administration of tryptophan prevents development of DOCA-salt-induced hypertension in rats, Can. J. Physiol. Pharmacol., 65: 753–764.
Fregly, M.J., Sumners, C., and Cade, J.R., 1989, Effect of chronic dietary treatment with L-tryptophan on the maintenance of hypertension in spontaneously hypertensive rats, Can. J. Physiol. Pharmacol., 67: 656–662.
Henley, W.N., Fregly, M.J., Wilson, K.M., and Hathaway, S., 1986, Physiologic responses to chronic dietary tyrosine supplementation in DOCA-salt-treated rats, Pharmacology, 33: 334–347.
Lockley, O.E., Fregly, M.J., and Fater, D.C., 1985, Effect of L-p-tyrosine on the development of renal hypertension in rats, Pharmacology, 31: 132–149.
Sved, A.F., van Itallie, C.M., and Fernstrom, J.D., 1982, Studies on the antihypertensive action of L-tryptophan, J. Pharmacol. Exp. Therap., 221: 329–333.
Wilson, K.M., Sumners, C., Hathaway, S., and Fregly, M.J., 1986, Mineralo-corticoids modulate central angiotensin II receptors in rats, Brain Res., 382: 87–96.
Wolf, W.A., and Kuhn, D.M., 1984, Effects of L-tryptophan on blood pressure in normotensive and hypertensive rats, J. Pharmacol. Exp. Therap., 230: 324–329.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Fregly, M.J. (1991). Effects of Tryptophan on the Development of Deoxycorticosterone Acetate (DOCA)-Induced Hypertension in Rats. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_80
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5952-4_80
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5954-8
Online ISBN: 978-1-4684-5952-4
eBook Packages: Springer Book Archive