Effects of L-Tryptophan on the Brainstem Indole and Catecholamine Metabolites in Spontaneously Hypertensive Rats
L-Tryptophan has several beneficial effect in mammals including humans. The amino acid is known to alleviate insomnia (Hartman and Greenwald, 1984), and it does act as a natural tranquilizer as well as an analgesic (Lytle et al., 1975; Hosobuchi et al., 1980a,b). Two recent reports (Sved et al., 1982; Wolf and Kuhn, 1984) and our current laboratory observations (this paper) indicate that L-tryptophan elicits pronounced antihypertensive effects in spontaneously hypertensive rats (SHRs). Wistar-Kyoto rats (WKYs) were utilized as normotensive counterparts of SHRs in our experiments.
KeywordsBiogenic Amine Catecholamine Metabolite Tryptophan Loading Regular Blood Pressure Control Brainstem
Unable to display preview. Download preview PDF.
- Brubaker, A., 1988, personal communication, Bioanalytical Systems, Inc., West Lafayette, Indiana.Google Scholar
- Freed, C.R., Echizen, H., and Bhaskaran, D., 1986, Serotonin metabolism and blood pressure regulation: insights form brain tissue assays and in vivo electrochemical recording, in: “Monitoring Neurotransmitter Release during Behavior”, Joseph, M.H., Fillenz, M., MacDonald, I.A., and Marsden, C.A., eds., Ellis Horwood Ltd., Chichester, England, pp. 133–143.Google Scholar
- Hartman, E., and Greenwald, D., 1984, Tryptophan and human sleep, in: “Progress in Tryptophan and Serotonin Research”, Schlossberger, H.G., Kochen, W., Linzen, B., and Steinhart, H., eds., de Gruyter, Berlin, pp. 297–304.Google Scholar
- Hosobuchi, Y., Rossier, J., and Bloom, F.E., 1980b, Oral loading with L-tryp-tophan may augment the simultaneous release of ACTH and beta-endorphin that accompanies periaqueductal stimulation in humans, in: “Neural Pep-tides and Neuronal Communication”, Costa, E., and Trabucchi, M., eds., Raven Press, New York, pp. 563–570.Google Scholar
- Kissinger, P.T., 1984, Liquid chromatography/electrochemistry determination of biogenic amines: improved performance using low dead volume multiple electrode transducers, in: “Progress in Tryptophan and Serotonin Research”, Schlossberger, H.G., Kochen, W., Linzen, B., and Steinhart, H., eds., de Gruyter, Berlin, pp. 45–43.Google Scholar
- Udenfriend, S., 1976, Committee on care and use of spontaneously hypertensive rats (SHRs), ILAR News, 19: G1–G20.Google Scholar