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Specific Binding of L-Tryptophan to Serum Albumin and its Function in Vivo

  • E. Sasaki
  • K. Saito
  • Y. Ohta
  • I. Ishiguro
  • Y. Nagamura
  • R. Shinohara
  • H. Takahashi
  • O. Tagaya
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Many kinds of organic anions such as long-fatty acids, bilirubin, bile acids and hormones, bind to albumin in the plasma. L-Tryptophan (Trp) also binds to albumin in the plasma, and this property is quite different from those of other amino acids (Macmenamy and Oncley, 1958). Recent studies on the transport of organic anions into liver cells using perfused rat liver have suggested that ligands tightly bound to albumin rather than unbound li-gands are transferred into liver cells readily, and that hepatic uptake of ligands is primarily mediated by the direct interactions between albumin-ligand complexes and the surface of liver cells (Weisigar et al., 1981).

Keywords

Organic Anion Left Jugular Vein Liver Cell Surface Specific Binding Ability Fresh Liver Homogenate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • E. Sasaki
    • 1
  • K. Saito
    • 1
  • Y. Ohta
    • 1
  • I. Ishiguro
    • 1
  • Y. Nagamura
    • 1
  • R. Shinohara
    • 1
  • H. Takahashi
    • 1
  • O. Tagaya
    • 2
  1. 1.Fujita-Gakuen Health UniversityToyoake AichiJapan
  2. 2.Eisai Co. Ltd.Kawashima Gifu 483Japan

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