The Role of Transaminations in the Pharmacological Effects of Indole-3-Pyruvic Acid
Indole-3-pyruvic acid (IPA), the keto-analog of tryptophan, is very much diffused in plants, where it can act as a phytohormone. In the past, it has been used as a substitute for tryptophan, with the aim to stimulate growth in rats (Jackson, 1930) or in chickens (Grigoriev and Truzhnikova, 1971). More recently, it has been shown that IPA decreases kynurenine formation by inhibiting tryptophan-2,3-dioxygenase (TPO; EC 188.8.131.52) (Lavaggi et al., 1987) and increases serotonin turnover in rat brains, inducing remarkable sedation and analgesia (Bacciottini et al., 1987). Because IPA can interfere with aromatic aminoacid metabolism, acting as substrate or inhibitor of transami-inases, the present study was designed to find possible relationships between transaminases present in mammalian bodies and pharmacological effects observed after IPA administration.
KeywordsPharmacological Effect Pyruvic Acid Mammalian Body Pathologic Stress Tryptophan Pyrrolase
Unable to display preview. Download preview PDF.
- Grigoriev, N.G., and Truzhnikova, T.M., 1971, Formation of tryptophan from 3-indolylpyruvic acid in the organism of chicks, Sel’skokhoz. Biol., 6: 97–101.Google Scholar
- Jackson, R.W., 1930, Indole derivatives in connection with a diet deficient in tryptophan, J. Biol. Chem., 84: 1–21.Google Scholar
- Lavaggi, M.V., Politi, V., De Luca, G., and Gorini, A., 1987, Effects of indole-3-pyruvic acid on tryptophan pyrrolase activity in vitro and in vivo, in: “Progress in Tryptophan and Serotonin Research”, Bender, D.A., Joseph, M.H., Kochen, W., and Steinhart, H., eds., de Gruyter, Berlin, pp. 51–54.Google Scholar