Brain-Specific Control of Kynurenic Acid Production by Depolarizing Agents

  • J. B. P. Gramsbergen
  • W. A. Turski
  • R. Schwarcz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


Kynurenic acid (KYNA), a prominent tryptophan metabolite found in high concentration in urine, has recently attracted the attention of neuroscien-tists studying the function of excitatory amino acids in the brain. KYNA, which is present in the mammalian brain (Carlà et al., 1988; Turski et al., 1988; cf. Moroni et al., this volume), is a neuroinhibitory compound which exerts its effect by interacting with all three established ionotropic excitatory amino acid receptors (Foster and Fagg, 1984). In experimental systems, KYNA has also been shown to act as a neuroprotectant and anticonvulsant (Foster et al., 1984; Germano et al., 1987). Because of the inferred possible role of KYNA in human neuropsychiatrie disorders, it therefore became of interest to examine brain mechanisms which control the function of endogenous KYNA.


Quinolinic Acid Liver Slice Kynurenic Acid Excitatory Amino Acid Receptor KYNA Production 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • J. B. P. Gramsbergen
    • 1
  • W. A. Turski
    • 1
  • R. Schwarcz
    • 1
  1. 1.Maryland Psychiatric Research CenterBaltimoreUSA

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