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Kynurenine-Pyruvate Aminotransferase in Rat Kidney and Brain

  • T. Ishikawa
  • E. Okuno
  • M. Tsujimoto
  • M. Nakamura
  • R. Kido
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Kynurenic acid, the product of kynurenine aminotransferase, has increasingly attracted attention because of its physiological effects in the brain, such as blockade of the neurotoxicity induced by quinolinic acid in rat (Foster et al., 1984) or decrease of the stroke size and deficits in human (Germano et al., 1987). Also, it can protect neonatal rats from hypoxia-induced brain edema (Simon et al., 1986).

Keywords

Ammonium Sulfate Quinolinic Acid Kynurenic Acid Pyridoxal Phosphate Brain Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Carlà, V., Lombardi, G., Beni, M., Russi, P., Moneti, G., and Moroni, F., 1988, Identification and measurement of kynurenic acid in the rat brain and other organs, Anal. Biochem., 169: 89–94.PubMedCrossRefGoogle Scholar
  2. Foster, A.C., Vezzani, A., French, E.D., and Schwarcz, R., 1984, Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid, Neurosci. Lett., 48: 273–278.PubMedCrossRefGoogle Scholar
  3. Germano, I.M., Pitts, L.H., Meldrum, B.S., Bartkowski, H.M., and Simon, R.P., 1987, Kynurenate inhibition of cell excitation decreases stroke size and deficits, Ann. Neurol., 22: 730–734.PubMedCrossRefGoogle Scholar
  4. Minatogawa, Y., Noguchi, T., and Kido, R., 1974, Kynurenine pyruvate trans-aminase in rat brain, J. Neurochem., 23: 271–272.PubMedCrossRefGoogle Scholar
  5. Noguchi, T., Minatogawa, Y., Okuno, E., Nakatani, M., Morimoto, M., and Kido, R., 1975, Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats, Biochem. J., 151: 399–406.Google Scholar
  6. Noguchi, T., and Kido, R., 1976, Identity of kynurenine:pyruvate aminotrans-ferase with histidine:pyruvate aminotransferase, Hoppe-Seyler’s Z. Physiol. Chem., 357: 649–656.PubMedCrossRefGoogle Scholar
  7. Okuno, E., Köhler, C., and Schwarcz, R., 1987, Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain, J. Neurochem., 49: 771–780.PubMedCrossRefGoogle Scholar
  8. Okuno, E., Minatogawa, Y., Nakamura, M., Kamoda, N., Nakanishi, J., Makino, M., and Kido, R., 1980, Crystallization and characterization of human liver kynurenine-glyoxylate aminotransferase, Biochem. J., 189: 581–590.PubMedGoogle Scholar
  9. Simon, R.P., Young, R.S.K., Stont, S., and Cheng, S., 1986, Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia, Neurosci. Lett., 71: 361–364.PubMedCrossRefGoogle Scholar
  10. Tobes, M.C., and Mason, M., 1975, L-kynurenine aminotransferase and L-α-aminoadipate aminotransferase, Biochem. Biophys. Res. Commun., 62: 390–397.PubMedCrossRefGoogle Scholar
  11. Tobes, M.C., and Mason, M., 1977, α-Aminoadipate aminotransferase and kynurenine aminotransferase: purification, characterization and further evidence for identity, J. Biol. Chem., 252: 4591–4599.PubMedGoogle Scholar
  12. Towbin, H., Staehlin, T., and Gordon, J., 1979, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sects: procedure and some applications, Proc. Nat. Acad. Sci. USA, 76: 4350–4354.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • T. Ishikawa
    • 1
  • E. Okuno
    • 1
  • M. Tsujimoto
    • 1
  • M. Nakamura
    • 1
  • R. Kido
    • 1
  1. 1.Dept. of BiochemistryWakayama Medical CollegeWakayama 640Japan

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