Non-Competitive Inhibition of 3-Hydroxyanthranilate-3, 4-Dioxygenase by 4-Chloro-3-Hydroxyanthranilic Acid in Whole Brain of Rat
The catabolism of L-tryptophan through the kynurenine pathway has long been recognized as the predominant route for systemic L-tryptophan metabolism and synthesis of nicotinamide containing nucleotides in mammalian species (see Bender et al., 1982). The potential importance of this pathway in brain is highlighted by the fact that many intermediates and products of the kynurenine pathway, including quinolinic acid (QUIN), are neuroactive (Lapin, 1982; Perkins and Stone, 1983; Schwarcz et al., 1983).
KeywordsQuinolinic Acid Kynurenine Pathway Muconic Acid Lilly Research Laboratory Negative Chemical Ionization Mass
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