Increased L-Tryptophan, 5-Hydroxyindoleacetic Acid, 3-Hydroxykynurenine and Quinolinic Acid Concentrations in Cerebral Cortex Following Systemic Endotoxin Administration

  • M. P. Heyes
  • B. J. Quearry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


Systemic infections and administration of lipopolysaccharide (LPS) are known to increase L-tryptophan (L-TRP) release from skeletal muscle, accelerate systemic L-TRP catabolism through the kynurenine pathway (Rapoport et al., 1970; Takikawa et al., 1986), and increase the excretion of L-kynurenine and xanthurenic acid (Rapoport et al., 1970; Takikawa et al., 1986). This increase in kynurenine pathway metabolites may, in part, be secondary to the induction of indoleamine-2, 3-dioxygenase (IDO), the first enzyme in the kynurenine pathway in extrahepatic tissues (Takikawa et al., 1986; Yoshida et al., 1986). Although there are numerous reports on the effects of infection and LPS on systemic L-TRP metabolism, the effects of immunologie stimulation on brain L-TRP metabolism have received little attention.


Cerebral Cortex Quinolinic Acid Kynurenine Pathway Extrahepatic Tissue Xanthurenic Acid 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. P. Heyes
    • 1
  • B. J. Quearry
    • 1
  1. 1.Laboratory of Clinical Science, NIMHSection on Analytical BiochemistryBethesdaUSA

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