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Increased L-Tryptophan, 5-Hydroxyindoleacetic Acid, 3-Hydroxykynurenine and Quinolinic Acid Concentrations in Cerebral Cortex Following Systemic Endotoxin Administration

  • M. P. Heyes
  • B. J. Quearry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Systemic infections and administration of lipopolysaccharide (LPS) are known to increase L-tryptophan (L-TRP) release from skeletal muscle, accelerate systemic L-TRP catabolism through the kynurenine pathway (Rapoport et al., 1970; Takikawa et al., 1986), and increase the excretion of L-kynurenine and xanthurenic acid (Rapoport et al., 1970; Takikawa et al., 1986). This increase in kynurenine pathway metabolites may, in part, be secondary to the induction of indoleamine-2, 3-dioxygenase (IDO), the first enzyme in the kynurenine pathway in extrahepatic tissues (Takikawa et al., 1986; Yoshida et al., 1986). Although there are numerous reports on the effects of infection and LPS on systemic L-TRP metabolism, the effects of immunologie stimulation on brain L-TRP metabolism have received little attention.

Keywords

Cerebral Cortex Quinolinic Acid Kynurenine Pathway Extrahepatic Tissue Xanthurenic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. P. Heyes
    • 1
  • B. J. Quearry
    • 1
  1. 1.Laboratory of Clinical Science, NIMHSection on Analytical BiochemistryBethesdaUSA

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