Quinolinic Acid Concentrations are Increased in Cerebrospinal Fluid of Rhesus Macaques (Macaca Mulatta) Naturally Infected with Simian Retrovirus Type
Infection of macaques in captivity with simian retrovirus type-D (SRV-D) is associated with reductions in T4 cell counts, immunosuppression, neoplasms and opportunistic infections (Arthur et al., 1986; King, 1986). This disease is referred to as simian acquired immunodeficiency syndrome (SAIDS). Infection of macaques with SRV-D currently occurs naturally in the primate colony at the NIH. The symptoms of SAIDS closely resemble the clinical features of patients with acquired immune deficiency syndrome (AIDS) which is caused by infection with the human immunodeficiency virus (HIV).
KeywordsAcquire Immune Deficiency Syndrome Quinolinic Acid Kynurenine Pathway Excitatory Amino Acid Receptor Acquire Immune Deficiency Syndrome Patient
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