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Quinolinic Acid Concentrations are Increased in Cerebrospinal Fluid of Rhesus Macaques (Macaca Mulatta) Naturally Infected with Simian Retrovirus Type

  • M. P. Heyes
  • M. Gravell
  • M. April
  • D. Blackmore
  • W. T. London
  • J. A. Yergey
  • S. P. Markey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Infection of macaques in captivity with simian retrovirus type-D (SRV-D) is associated with reductions in T4 cell counts, immunosuppression, neoplasms and opportunistic infections (Arthur et al., 1986; King, 1986). This disease is referred to as simian acquired immunodeficiency syndrome (SAIDS). Infection of macaques with SRV-D currently occurs naturally in the primate colony at the NIH. The symptoms of SAIDS closely resemble the clinical features of patients with acquired immune deficiency syndrome (AIDS) which is caused by infection with the human immunodeficiency virus (HIV).

Keywords

Acquire Immune Deficiency Syndrome Quinolinic Acid Kynurenine Pathway Excitatory Amino Acid Receptor Acquire Immune Deficiency Syndrome Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. P. Heyes
    • 1
  • M. Gravell
    • 2
  • M. April
    • 3
  • D. Blackmore
    • 4
  • W. T. London
    • 5
  • J. A. Yergey
    • 6
  • S. P. Markey
    • 1
  1. 1.Laboratory of Clinical Science NIMHSection on Analytical BiochemistryUSA
  2. 2.Laboratory of Central Nervous System Studies NINDSUSA
  3. 3.NIH Animal CentrePoolesvilleUSA
  4. 4.Comparative Medicine Branch NIEMSUSA
  5. 5.Georgetown UniversityWashingtonUSA
  6. 6.Section of Analytical ChemistryLaboratory of Clinical Studies NIAAABethesdaUSA

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