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On Kynureninase Activity

  • Y. Shibata
  • F. Takeuchi
  • R. Tsubouchi
  • M. Haneda
  • T. Ohta
  • M. Nakatsuka
  • Y. Nisimoto
  • T. Tamai
  • S. Nomura
  • H. Fujimoto
  • M. Sakata
  • T. Maesaki
  • K. Goda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

In 1952, Yahito Kotake et al. reported that xanthurenic acid (XA) might be a diabetogenic agent in vitamin B6 (B6)-deficient rats. From that time, many studies have been performed in B6-deficient rats and in diabetic (DM) patients. The results are as follows:
  1. 1)

    The pyridoxal phosphate/pyridoxal ratio in plasma decreased in DM patients compared with the control group [DM group: 0.54 (N = 9); control group: 3.84 (N = 8)], suggesting that pyridoxal kinase activity may be inhibited in DM patients (Hattori et al., 1984).

     

Keywords

Pyridoxal Phosphate Xanthurenic Acid Experimental Diabetes Mellitus Kynurenine Aminotransferase Pyridoxal Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hattori, M., Kotake, Y., Kotake, Y., Otsuka, H., and Shibata, Y., 1984, Studies on the urinary excretion of xanthurenic acid in diabetes, in: “Progress in Tryptophan and Serotonin Research”, Schlossberger, H.G., Kochen, W., Linzen, B., and Steinhart, H., eds., de Gruyter, Berlin, pp. 347–354.Google Scholar
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  7. Takeuchi, F., Tsubouchi, R., and Shibata, Y., 1985, Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridox-amine 5-phosphate oxidase In vivo. Biochem. J., 277: 537–544.Google Scholar
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Y. Shibata
    • 1
  • F. Takeuchi
    • 1
  • R. Tsubouchi
    • 1
  • M. Haneda
    • 1
  • T. Ohta
    • 1
  • M. Nakatsuka
    • 1
  • Y. Nisimoto
    • 1
  • T. Tamai
    • 1
  • S. Nomura
    • 1
  • H. Fujimoto
    • 1
  • M. Sakata
    • 1
  • T. Maesaki
    • 1
  • K. Goda
    • 2
  1. 1.Department of BiochemistryAichi Medical University NagakuteAichiJapan
  2. 2.Kobe-Gakuin UniversityKobe-City Hyogo 673Japan

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