Inhibition of Tryptophan → Niacin Metabolism by Dietary Leucine and by Leucine and 2-Oxo-isocaproate in vitro

  • D. A. Bender
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


A relative excess of leucine in dietary proteins has been implicated in the etiology of the tryptophan-niacin deficiency disease pellagra in those parts of India where the dietary staple is jowar (Sorghum vulgare) (Gopalan and Srikantia, 1960).


Xanthurenic Acid Relative Excess Dietary Staple Sorghum Vulgare Tryptophan Diet 
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  1. Bender, D.A., 1983, Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine, Br. J. Nutr., 50: 25–32.PubMedCrossRefGoogle Scholar
  2. Gopalan, C., and Srikantia, S.G., 1960, Leucine and pellagra, Lancet, 1: 954–957.PubMedCrossRefGoogle Scholar
  3. Magboul, B.I., and Bender, D.A., 1983, Effects of a dietary excess of leucine on the synthesis of nicotinamide nucleotides in the rat, Br. J. Nutr., 49: 321–329.PubMedCrossRefGoogle Scholar
  4. Salter, M., Bender, D.A., and Pogson, C.I., 1985, Leucine and tryptophan metabolism in rats, Biochem. J., 225: 277–281.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • D. A. Bender
    • 1
  1. 1.Department of BiochemistryUniversity College LondonLondonUK

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