Circadian Patterns of Salivary Melatonin and Urinary 6-Sulfatoxy-Melatonin before and after A 9 Hour Time-Shift
During the past decade, many laboratories have replaced melatonin (MT) determination in serum by the measurement of the hormone in saliva, or its main metabolite 6-sulfatoxymelatonin (MTS) in urine. Advantages of these methods include non-invasive sampling techniques which have proven extremely beneficial during longitudinal studies in humans; in addition, determination of urinary MTS excretion allows to calculate more closely the total amount of MT production. Several groups have reported high correlations between serum and salivary MT on the one hand (Vakkuri 1985; Miles et al., 1987; Nowak et al., 1987), and between serum MT and urinary MTS on the other (Markey et al., 1985; Bojkowski et al., 1987). However, all these studies were done under baseline conditions, i.e. with subjects living in a regular 24 h-time pattern.
KeywordsTime Shift Circadian Pattern Aerospace Medicine Partial Sleep Deprivation Plasma Melatonin Level
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- Nowak, R., McMillen, I.C., Redman, J., and Short, R.V., 1987, The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxy-melatonin sulphate excretion rates: two noninvasive techniques for monitoring human circadian rhythmicity, Clin. Endocrinol., 27: 445–452.CrossRefGoogle Scholar