Evidence for the Preferential Production of 3-Hydroxyanthranilic Acid from Anthranilic Acid in the Rat Brain
The excitotoxic brain metabolite quinolinic acid (QUIN) has been hypo-thetically linked to the pathogenesis of neurodegenerative and seizure disorders. Thus, intracerebral QUIN injections in rats produce patterns of nerve cell loss in the hippocampus and striatum which are remarkably similar to those seen in temporal lobe epilepsy and Huntington’s disease, respectively. More recently (Heyes et al., this volume), QUIN has also been specula-tively related to the pathogenesis of viral disorders such as AIDS.
KeywordsTemporal Lobe Epilepsy Quinolinic Acid Anthranilic Acid Kynurenine Pathway Preferential Production
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