Evidence for the Preferential Production of 3-Hydroxyanthranilic Acid from Anthranilic Acid in the Rat Brain

  • H. Baran
  • R. Schwarcz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


The excitotoxic brain metabolite quinolinic acid (QUIN) has been hypo-thetically linked to the pathogenesis of neurodegenerative and seizure disorders. Thus, intracerebral QUIN injections in rats produce patterns of nerve cell loss in the hippocampus and striatum which are remarkably similar to those seen in temporal lobe epilepsy and Huntington’s disease, respectively. More recently (Heyes et al., this volume), QUIN has also been specula-tively related to the pathogenesis of viral disorders such as AIDS.


Temporal Lobe Epilepsy Quinolinic Acid Anthranilic Acid Kynurenine Pathway Preferential Production 
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  1. Baran, H., and Schwarcz, R., 1990, Presence of 3-hydroxyanthranilic acid in rat tissues and evidence for its production from anthranilic acid in the brain, J. Neurochem., 55: 738–744.PubMedCrossRefGoogle Scholar
  2. Foster, A.C., White, R.J., and Schwarcz, R., 1986, Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. J. Neurochem., 47: 23–30.PubMedCrossRefGoogle Scholar
  3. Okuno, E., Köhler, C., and Schwarcz, R., 1987, Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain, J. Neurochem., 49: 771–780.PubMedCrossRefGoogle Scholar
  4. Schwarcz, R., Baran, H., and Okuno, E., 1989, Anthranilate hydroxylase in rat brain, Soc. Neurosci. Abstr., 15: 328.6.Google Scholar
  5. Speciale, C., Ungerstedt, U., and Schwarcz, R., 1989, Production of extracellular quinolinic acid in the striatum studied by microdialysis in unanes-thetized rats, Neurosci. Lett., 104: 345–350.PubMedCrossRefGoogle Scholar
  6. Ueda, T., Otsuka, H., Goda, K., Ishiguro, I., Naito, J., and Kotake, Y., 1978, The metabolism of [carobxyl-14C]anthranilic acid. I. The incorporation of radioactivity into NAD+ and NADP+, J. Biochem., 84: 687–696.PubMedGoogle Scholar
  7. Watkins, J.C., and Collingridge, G.L., eds., 1989, “The NMDA Receptor”, IRL, Oxford, 242 pp.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • H. Baran
    • 1
  • R. Schwarcz
    • 1
  1. 1.Maryland Psychiatric Research CenterBaltimoreUSA

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