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The Excretion of N1-Methyl-2-Pyridone-5-Carboxylic Acid and Related Compounds in Human Subjects after Oral Administration of Nicotinic Acid, Trigonalline and N1-Methyl-2-Pyridone-5-Carboxylic Acid

  • S. Yuyama
  • T. Suzuki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

During the development of a procedure for the determination of trigonel-line (Tg) in human urine (Yuyama and Suzuki, 1987), an organic acid with a similar ultra-violet spectrum was isolated. The compound was found to be N1-methyl-2-pyridone-5-carboxylic acid (Tg-2Py) (Lindenblad et al., 1956), which Holman et al. (1950) were unable to detect in normal human urine. In the present study, Tg-2Py was determined by HPTLC. The urinary excretion of Tg-2Py, Tg and N1-methylnicotinamide (MNA) were determined before and after the oral administration of nicotinic acid (NiA), Tg and Tg-2Py.

Keywords

Healthy Subject Oral Administration Urinary Excretion Nicotinic Acid Human Urine 
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References

  1. Holman, W.I.M., and Lange, D.J., 1950, Metabolism of nicotinic acid and related compounds by humans, Nature, 165: 604–605.PubMedCrossRefGoogle Scholar
  2. Lindenblad, G.E., Kaihara, M., and Price, J.M., 1956, The occurrence of N-methyl-2-pyridone-5-carboxylic acid and its glycine conjugate in normal human urine, J. Biol. Chem., 219: 893–901.PubMedGoogle Scholar
  3. Yuyama, S., and Suzuki, T., 1987, Urinary excretion of trigonelline and N1-methylnicotinamide by human beings and rats following oral administration of nicotinic acid or trigonelline, in: “Progress in Tryptophan and Serotonin Research”, Bender, D.A., Joseph, M.H., Kochen, W., and Steinhart H., eds., de Gruyter, Berlin, pp. 197–202.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • S. Yuyama
    • 1
  • T. Suzuki
    • 1
  1. 1.Department of Nutrition and BiochemistryThe Institute of Public HealthTokyo 108Japan

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