The Excretion of N1-Methyl-2-Pyridone-5-Carboxylic Acid and Related Compounds in Human Subjects after Oral Administration of Nicotinic Acid, Trigonalline and N1-Methyl-2-Pyridone-5-Carboxylic Acid
During the development of a procedure for the determination of trigonel-line (Tg) in human urine (Yuyama and Suzuki, 1987), an organic acid with a similar ultra-violet spectrum was isolated. The compound was found to be N1-methyl-2-pyridone-5-carboxylic acid (Tg-2Py) (Lindenblad et al., 1956), which Holman et al. (1950) were unable to detect in normal human urine. In the present study, Tg-2Py was determined by HPTLC. The urinary excretion of Tg-2Py, Tg and N1-methylnicotinamide (MNA) were determined before and after the oral administration of nicotinic acid (NiA), Tg and Tg-2Py.
KeywordsHealthy Subject Oral Administration Urinary Excretion Nicotinic Acid Human Urine
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- Yuyama, S., and Suzuki, T., 1987, Urinary excretion of trigonelline and N1-methylnicotinamide by human beings and rats following oral administration of nicotinic acid or trigonelline, in: “Progress in Tryptophan and Serotonin Research”, Bender, D.A., Joseph, M.H., Kochen, W., and Steinhart H., eds., de Gruyter, Berlin, pp. 197–202.Google Scholar