Detection of a New Intermediate Product of Indolealkylamine Metabolism in the Brain

  • H. Rommelspacher
  • R. Susilo
  • M. Schühle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Recently, we have isolated a new biogenic aldehyde adduct following the incubation of tryptamine with brain homogenate from rat, bovine and pig. The compound could be identified as (4R)-2-(3′-indolyl-methyl)-1, 3-thiazolidine-4-carboxylic acid (ITCA), a condensation product of indo1eacetaldehyde (IAAL) with L-cysteine (Susilo et al., 1987, 1988). Similar experiments were conducted with 5-hydroxytryptamine (5-HT).

Keywords

Aldehyde Adduct Monoamine Lyase Thiazolidine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cushman, D.W., and Cheung, H.S., 1971, Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung, Biochem. Pharmacol., 20: 1637–1648.CrossRefGoogle Scholar
  2. Krajl, M., 1965, A rapid mcirofluorimetric determination of monoamine oxi-dase, Biochem. Pharmacol., 14: 1683–1685.CrossRefGoogle Scholar
  3. Susilo, R., Höfle, G., and Rommelspacher, H., 1987, Degradation of trypta-mine in pig brain: identification of a new condensation product, bdBiochem. Biophys. Res. Comm., 148: 1045–1052.CrossRefGoogle Scholar
  4. Susilo, R., Rommelspacher, H., and Höfle, G., 1989, Formation of thiazol-idine-4-carboxylic acid represents a main metabolic pathway of 5-hydroxy-tryptamine in rat brain, J. Neurochem., 52: 1793–1800.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • H. Rommelspacher
    • 1
  • R. Susilo
    • 1
  • M. Schühle
    • 1
  1. 1.Department of NeuropsychopharmacologyFree UniversityBerlin 19Germany

Personalised recommendations