Detection of a New Intermediate Product of Indolealkylamine Metabolism in the Brain
Recently, we have isolated a new biogenic aldehyde adduct following the incubation of tryptamine with brain homogenate from rat, bovine and pig. The compound could be identified as (4R)-2-(3′-indolyl-methyl)-1, 3-thiazolidine-4-carboxylic acid (ITCA), a condensation product of indo1eacetaldehyde (IAAL) with L-cysteine (Susilo et al., 1987, 1988). Similar experiments were conducted with 5-hydroxytryptamine (5-HT).
KeywordsBrain Homogenate Indoleacetic Acid Condensation Product Gaba Uptake Carboxylic Acid Derivative
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