Advertisement

Content of Tryptophan in Human Hair

  • G. Allegri
  • C. Costa
  • M. Biasiolo
  • R. Arban
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

Previous papers have shown that tryptophan is involved in the process of melanogenesis (Musajo et al., 1966; Musajo et al., 1969; De Antoni et al., 1970; Allegri et al., 1972; De Antoni et al., 1974; Costa et al., 1975). In fact, tryptophan and also kynurenines and indolic hydroxylated metabolites form melanins by the action of tyrosinase from Sepia officinalis and of poly-phenoloxydase from potato and from Psalliota campestris mushroom (Musajo et al., 1966; Musajo et al., 1969; De Antoni et al., 1970). The study of the precursors which form during the process of melanization of tryptophan revealed that one of the substances which give rise to the formation of black pigments is 3-hydroxykynurenine (Musajo et al., 1966; Musajo et al., 1969).

Keywords

Human Hair Hair Color Black Pigment Kynurenine Pathway White Hair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allegri, G., De Antoni, A., Baccichetti, F., and Costa, C., 1972, Incorporation of D,L-tryptophan-benzene ring 14C(U) and D, L-tryptophan-methylene-14C into the melanin of mouse Harding-Passey melanoma, Gazz. Chim. Ital., 102: 426–430.Google Scholar
  2. Barnicot, N.A., 1959, Paper chromatography of human hair follicles and hair extracts, Br. J. Derm., 71: 303–308.CrossRefGoogle Scholar
  3. Coppini, D., Benassi, C.A., and Montorsi, M., 1959, Quantitative determination of tryptophan metabolites (via kynurenine) in biologic fluids, Clin. Chem., 5: 391–401.PubMedGoogle Scholar
  4. Costa, C., Allegri, G., and De Antoni, A., 1975, Studies on melanogenesis of tryptophan in Harding-Passey mouse melanoma, Acta Vitaminol. Enzymol., 29: 223–226.PubMedGoogle Scholar
  5. Costa, C., Bettero, A., and Allegri, G., 1987, Rapid measurement of tryptophan, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in human CSF by selective fluorescence and HPLC, Gior. It. Chim. Clin., 12: 307–312.Google Scholar
  6. De Antoni, A., Allegri, G., and Costa, C., 1970, Azione di sistemi enzima-tici ad attivita polifenolossidasica sul triptofano e suoi derivati metabolici, Gazz. Chim. Ital., 100: 1039–1049.Google Scholar
  7. De Antoni, A., Allegri, G., Costa, C., and Bordin, F., 1974, Melanogenesis from tryptophan. Biogenetic experiments with Harding-Passey mouse melanoma, Experientia, 30: 600–604.PubMedCrossRefGoogle Scholar
  8. Fitzpatrick, T.B., Brunet, P., and Kukita, A., 1958, Nature of hair pigment, in: “The Biology of Hair Growth”, Montagna, W., and Ellis, R.A., eds., Academic Press, New York, pp. 255–303.Google Scholar
  9. Musajo, L., Benassi, C.A., Allegri, G., Levorato, E., and De Antoni, A., 1966, Azione della tirosinasi sul triptofano e su suoi derivati metabolici, Chim. e Ind., 48: 1221.Google Scholar
  10. Musajo, L., De Antoni, A., Allegri, G., Levorato, E., and Benassi, C.A., 1969, Azione della tirosinasi sul triptofano e su suoi derivati metabolici, in: “Chimica del Farmaco e dei Prodotti Biologicamente Attivi del CNR”, Roma, pp. 283–285.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • G. Allegri
    • 1
  • C. Costa
    • 1
  • M. Biasiolo
    • 1
  • R. Arban
    • 1
  1. 1.Department of Pharmaceutical SciencesPadova UniversityPadovaItaly

Personalised recommendations