The Effect of Aluminum on Rat Brain and Liver Quinolinic Acid Concentrations
Aluminum has been shown in a number of studies to cause intoxication and cell death in a variety of animal species. There is also considerable evidence that aluminum plays some role in the pathogenesis of Alzheimer’s disease and in encephalopathy suffered by patients undergoing hemodialysis. Fatal dialysis encephalopathy in patients undergoing haemodialysis was first described in 1972 by Alfrey et al. and was subsequently shown to be caused by the accumulation of aluminum in the grey matter (Alfrey et al., 1976). The aluminum is derived from aluminum containing antacids and from the dialysate itself.
KeywordsQuinolinic Acid Kynurenine Pathway Iron Porphyrin Dihydropteridine Reductase Aluminum Intoxication
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