Effects of Clomipramine on Extracellular Serotonin in the Rat Frontal Cortex

  • A. Adell
  • F. Artigas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)


The tricyclic antidepressant clomipramine (CIM) has been shown to inhibit the uptake of serotonin (5-hydroxytryptamine, 5-HT) into rat brain synaptosomes as well as into human platelets. The acute administration of CIM decreases 5-HT turnover (Carlsson and Lindqvist, 1978; Marco and Meek, 1979). This finding agrees with electrophysiological studies showing a reduction in the firing rate of 5-HT neurons after a single dose of CIM (Gallager and Aghajanian, 1975; Dresse and Scuvée-Moreau, 1979). The increased synaptic availability caused by the inhibition of 5-HT uptake possibly activates a feedback mechanism mediated by presynaptic and/or somatodendritic autoreceptors. This may lead to a decrease in the activity of 5-HT neurons thereby lowering its release.


Firing Rate Raphe Nucleus Dialysis Sample Lysergic Acid Dialysis Probe 
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  1. Carlsson, A., and Lindqvist, M., 1978, Effects of antidepressant agents on the synthesis of brain monoamines, J. Neural Transm., 43: 73–91.PubMedCrossRefGoogle Scholar
  2. Dresse, A.E., and Scuvée-Moreau, J., 1979, Action of antidepressants on the spontaneous firing of locus coeruleus and dorsal raphe neurons of the rat, in: “Catecholamines: Basic and Clinical Frontiers”, Usdin, E., Kopin, I.J., and Barchas, J., eds., Pergamon, New York, pp. 640–642.Google Scholar
  3. Friedman, E., and Cooper, T.B., 1983, Pharmacokinetics of chlorimipramine and its demethylated metabolite in blood and brain regions of rats treated acutely and chronically with chlorimipramine, J. Pharmacol. Exp. Ther., 225: 387–390.PubMedGoogle Scholar
  4. Gallager, D.W., and Aghajanian, G.K., 1975, Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3H-serotonin: correlations with serotonergic impulse flow, J. Pharmacol. Exp Ther., 193: 785–795.PubMedGoogle Scholar
  5. Marco, E.J., and Meek, J.L., 1979, The effects of antidepressants on serotonin turnover in discrete regions of rat brain, Naunyn-Schmiedeberg’s Arch. Pharmacol., 306: 75–79.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. Adell
    • 1
  • F. Artigas
    • 1
  1. 1.Department of NeurochemistryCSICBarcelonaSpain

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