The Regulation of Brain Kynurenic Acid Content: Focus on Indole-3-Pyruvic Acid
The actual interest in the role that kynurenic acid (KYNA), one of the first identified metabolic products of tryptophan, (Ellinger et al., 1904 in Heidelberger et al., 1949; see Fig. 1) may have in physiology or pathology stems from at least three groups of observations. First, KYNA antagonizes in a non-competitive manner excitatory amino acid (EAA) receptors (Perkins and Stone, 1982; Moroni et al., 1986); second, it prevents the excitotoxic actions of the related tryptophan (TRP) metabolite quinolinic acid (QUIN) (Foster et al., 1984) and reduces neuronal damage after anoxic and ischemic brain insults (Germano et al., 1987); and third, it is present in mammalian biological fluids and in the central nervous system (Moroni et al., 1988b).
KeywordsExcitatory Amino Acid Quinolinic Acid Kynurenic Acid Excitatory Amino Acid Receptor Brain Content
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- Kemp, J.A., Foster, A.C., Leeson, P.D., Priestley, T., Tridgett, R., Iversen, L.L., and Woodruff, G.N., 1988, 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex, Proc. Natl. Acad. Sci. USA, 85: 6547–6550.PubMedCrossRefGoogle Scholar
- Kuroda, Y., 1950, A contribution to the metabolism of tryptophan, J. Biochem., 37: 91–97.Google Scholar
- Neff, N.H., Tozer, T.N., and Brodie, B.B., 1967, Application of steady-state kinetics to studies of the transfer of 5-HIAA from brain to plasma, J. Pharmacol. Exp. Ther., 158: 214–218.Google Scholar