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Melatonin Interaction with the Benzodiazepine-GABA Receptor Complex in the CNS

  • L. Niles
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 294)

Abstract

The major inhibitory neurotransmitter, γ-aminobutyric acid (GABA) acts on a postsynaptic receptor complex which includes GABA and benzodiazepine (BZ) recognition sites and a chloride ionophore (Turner and Whittle, 1983). Pharmacological, biochemical and neurophysiological studies suggest that BZ agonists, such as diazepam, exert their central effects by enhancing lowaffinity GABA binding (DeFeudis, 1983; Olsen and Venter, 1986).

Keywords

Cortical Membrane Gaba Binding Diazepam Binding Diazepam Binding Inhibition Muscimol Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • L. Niles
    • 1
  1. 1.Department of Biomedical Sciences Division of NeuroscienceMcMaster UniversityHamiltonCanada

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