Kynurenate Forming Enzymes in Liver, Kidney and Brain
Kynurenate was discovered by Liebig in 1853. The name he chose for this compound is still appropriate, since it occurs in higher concentration in the urine of dogs and closely related species than in the urine of other animals (Gordon et al... 1936; Jackson, 1939; Brown and Price, 1956). The discovery of tryptophan by Hopkins and Cole (1901) was followed shortly by the observation (Ellinger, 1904) that kynurenate was a metabolite of this amino acid. By the time the conversion of tryptophan-14C to kynurenate-14C was demonstrated (Heidelberger et al., 1949), it came as no surprise. On the other hand, the Kotake school found that kynurenine was an intermediary metabolite of tryptophan (Kotake and Iwao, 1931) and a metabolic precursor of kynurenate (Kotake, 1931).
KeywordsQuinolinic Acid Aminotransferase Activity Kynurenic Acid Glyoxylic Acid Intermediary Metabolite
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