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Retro-, Intro- and Perspectives of Trypto-Fun

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Kynurenine and Serotonin Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 294))

Abstract

“I have a feeling, Dale, that if we can find the meaning of a color reaction like that [the reaction of Adamkiewicz], it may open up a way to new knowledge of the structure of the old protein molecule itself”. Shortly after Hopkins had said these words to his student Henry Dale (1948), he identified glyoxylic acid as the contaminant needed to give the blue color with commercial acetic acid and strong sulfuric acid, known now as the Hopkins-Cole-Adamkiewicz reaction, with most proteins. In 1901, he isolated the chromogenic protein constituent and named it (−)-tryptophan (Hopkins and Cole, 1901), after R. Neumeister who in 1890 observed it in impure form on digestion of protein with trypsin.

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Author information

Authors and Affiliations

  1. Institute Scholar, National Institutes of Health, Bethesda, Maryland, 20892, USA

    B. Witkop

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  1. B. Witkop
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Editors and Affiliations

  1. Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Robert Schwarcz

  2. McGill University, Montreal, Quebec, Canada

    Simon N. Young

  3. University of Wisconsin, Madison, Wisconsin, USA

    Raymond R. Brown

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© 1991 Plenum Press, New York

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Witkop, B. (1991). Retro-, Intro- and Perspectives of Trypto-Fun. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_1

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  • DOI: https://doi.org/10.1007/978-1-4684-5952-4_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5954-8

  • Online ISBN: 978-1-4684-5952-4

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