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Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors pp 97–104Cite as

Recombinant Human Insulin-Like Growth Factor I: Effects in Normal Subjects and Implications for Use in Patients

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 293))

Abstract

Two major forms of insulin-like growth factors (IGF-I and IGF-II) and their specific binding proteins have been detected in body fluids, including serum, cerebrospinal fluid, breast milk, lymph, and saliva. Extracts of almost any tissue reveal the presence of IGFs. Many cells in culture secret IGFs and various forms of their carrier proteins into the medium (1–3).

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References

  1. Daughaday WH, Rotwein P. Insulin-Like Growth Factors I and II Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations. Endocrine Rev 10:68–91, 1989.

    Article  CAS  Google Scholar 

  2. Humbel RE. Insulin-like Growth Factors I and II. Eur J Biochem 190:445–462, 1990.

    Article  PubMed  CAS  Google Scholar 

  3. Sara VR, Hall K. Insulin-Like Growth Factors and Their Binding Proteins. Physiol Rev 70:591–614, 1990.

    PubMed  CAS  Google Scholar 

  4. Froesch ER, Schmid Chr, Schwander J, Zapf J. Actions of Insulin-Like Growth Factors. Ann Rev Physiol 47:443–467, 1985.

    Article  CAS  Google Scholar 

  5. Hardouin S, Gourmelen M, Noguiez P, Seurin D, Roghani M, LeBouc Y, Povoa G, Merimee TJ, Hossenlopp P, Binoux M. Molecular Forms of Serum Insulin-Like Growth Factor (IGF)-Binding Proteins in Man: Relationships with Growth Hormone and IGFs and Physiological Significance. J Clin Endocrin Metabol 65:1291– 1301, 1989.

    Article  Google Scholar 

  6. Schoenle E, Zapf J, Humbel RE, Froesch ER. Insulin-Like Growth factor I Stimulates Growth in Hypophysectomized Rats. Nature 796:252–253, 1982.

    Article  Google Scholar 

  7. Van Buul-Offers S, Ueda I, Van den Brande JL. Biosynthetic Somatomedin C (SM-C/IGF-I) Increases the Length and Weight of Snell Dwarf Mice. Pediatric Res 20:825–827, 1986.

    Article  Google Scholar 

  8. Guler HP, Zapf J, Scheiwiller E, Froesch ER. Recombinant Human Insulin-Like Growth Factor I Stimulates Growth and Has Distinct Effects on Organ Size in Hypophysectomized Rats. Proc. Natl. Acad. Sci. 85:4889–4893, 1988.

    Article  PubMed  CAS  Google Scholar 

  9. Zapf J, Schmid C., Guler HP, Waldvogel M, Hauri C., Futo E, Hossenlopp P, Binoux M, Froesch ER. Regulation of Binding Proteins for Insulin-Like Growth Factors (IGF) in Man: Increased Expression of IGF Binding Protein-2 During IGF-I Treatment of Healthy Adults and in Patients with Extrapancreatic Tumor Hypoglycemia. J Clin Invest; 86:952–962, 1990.

    Article  PubMed  CAS  Google Scholar 

  10. Clemmons DR, Thissen JP, Maes M, Ketelslegers JM, Underwood LE. IGF-I infusion into hypophysectomized or protein deprived rats induces specific IGF-binding proteins in serum. Endocrinology 125:2967–2972, 1989.

    Article  PubMed  CAS  Google Scholar 

  11. Zapf J, Hauri C, Waldvogel M, Futo E, Hasler H, Binz K, Guler HP, Schmid Ch, Froesch ER. Recombiant human IGF-I its own specific carrier protein in hypophysectmoized and diabetic rats. Proc Natl Acad Sci 86: 3813–3817, 1989.

    Article  PubMed  CAS  Google Scholar 

  12. Guler HP, Zapf J, Froesch ER. Short-Term Metabolic Effects of Recombinant Human Insulin-Like Growth Factor in Healthy Adults. NEJM 317:137–140, 1987.

    Article  PubMed  CAS  Google Scholar 

  13. Laron Z, Klinger B, Erster B, Anin S. Effect of acute administration of insulin-like growth factor I in patients with Laron-type dwarfism. Lancet II: 1170–1172, 1988.

    Article  Google Scholar 

  14. Takano K, Hizuka N, Asakawa K, Sukegawa I, Shizume K, Demura H. Effects of sc administration of rhIGF-I on normal human subjects. Endocrinol Japon 37:309–317, 1990.

    Article  CAS  Google Scholar 

  15. Leahy JL, Vandekerkhove KM. Insulin-Like Growth Factor-I at Physiological Concentrations Is a Potent Inhibitor of Insulin Secretion. Endocrinology 126:1593–1598, 1990.

    Article  PubMed  CAS  Google Scholar 

  16. Van Schravendijk C, Heylen L, Van Den Brande JL, Pipeleers D. Effects of Insulin and IGF-I on the Secretory Activity of Pancreatic B-Cells. Diabetologia 32:551A, 1989.

    Google Scholar 

  17. Guler HP, Schmid Ch, Zapf J, Froesch ER. Effects of recombinant human IGF-I on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci 86:2868–2872, 1989.

    Article  PubMed  CAS  Google Scholar 

  18. Keller S, Schmid Ch, Zapf J, Froesch ER. Inhibition of insulin degradation by insulin-like growth factors I and II in human hepatoma (HepG2) cells. Acta Endocrin 121:279–285, 1989.

    CAS  Google Scholar 

  19. Livingston N, Pollare T, Lithell H, Arner P. Characterisation of Insulin-Like Growth Factor I Receptor in Skeletal Muscles of Normal and Insulin Resistant Subjects. Diabetologia 31:871–877, 1988.

    Article  PubMed  CAS  Google Scholar 

  20. Jacob R, Bowen L, Fryburg D, Fagin K, Tamborlane W, Shulman GI. Increased Metabolic Response to IGF-I in Insulin Resistant Diabetic BB Rats. Ann. Meeting Amer. Diab Assn., Detroit 1989, Abstract #261.

    Google Scholar 

  21. Dohm GL, Elton CW, Raju MS, Mooney ND, DiMarchi R, Pories WJ, Flickinger EG, Atkinson M, Caro JF. IGF-I stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM. Diabetes 39: 1028–1032, 1990.

    Article  PubMed  CAS  Google Scholar 

  22. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L. Somatomedin-C Mediates Growth Hormone Netative Feedback by Effects on Both the Hypothalamus and the Pituitary. Science 212:1279–1281, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Hiromi A, Molitch ME, Van Wyk JJ, Underwood LE. Human Growth Hormone and Somatomedin C Suppress the Spontaneous Release of Growth Hormone in Unanesthetized Rats. Endocrinology 113:1319, 1983.

    Article  Google Scholar 

  24. Yamashita S, Melmed S. Insulin-Like Growth Factor I Action on Rat Anterior Pituitary Cells: Suppression of Growth Hormone Secretion and Messenger Ribonucleic Acid Levels. Endocrinology 118:176–181, 1986.

    Article  PubMed  CAS  Google Scholar 

  25. Morita S, Yamashita S, Melmed S. Insulin-Like Growth Factor I Action on Rat Anterior Pituitary Cells: Effects of Intracellular Messengers on Growth Hormone Secretion and Messenger Ribonucleic Acid Levels. Endocrinology 121: 2000–2006, 1987.

    Article  PubMed  CAS  Google Scholar 

  26. Fagin JA, Brown A, Melmed S. Regulation of Pituitary Insulin-Like Growth Factor-I Messenger Ribonucleic Acid Levels in Rats Harboring Somatomammotropic Tumors: Implications for Growth Hormone Autoregulations. Endocrinology 122: 2204–2210, 1988.

    Article  PubMed  CAS  Google Scholar 

  27. Perriello G, De Feo P, Torlone E, Fanelli C, Santeusanio F, Brunetti P, Bolli GB. Nocturnal spikes of growth hormone secretion cause the dawn phenomenon in type I (insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin waning. Diabetologia 33:52–59, 1990.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Metabolic Unit, Department of Medicine, University Hospital, 8091, Zurich, Switzerland

    Katharina Wettstein, Jurgen Zapf & E. Rudolf Froesch

  2. Ciba-Geigy Corp., Summit, NJ, 07901, USA

    Hans-Peter Guler

  3. Ciba-Geigy AG, 4002, Basle, Switzerland

    Werner Schurr

Authors
  1. Hans-Peter Guler
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  2. Katharina Wettstein
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  3. Werner Schurr
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  4. Jurgen Zapf
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  5. E. Rudolf Froesch
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Editor information

Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

  2. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

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© 1991 Plenum Press, New York

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Guler, HP., Wettstein, K., Schurr, W., Zapf, J., Froesch, E.R. (1991). Recombinant Human Insulin-Like Growth Factor I: Effects in Normal Subjects and Implications for Use in Patients. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5949-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5951-7

  • Online ISBN: 978-1-4684-5949-4

  • eBook Packages: Springer Book Archive

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