Recombinant Human Insulin-Like Growth Factor I: Effects in Normal Subjects and Implications for Use in Patients

  • Hans-Peter Guler
  • Katharina Wettstein
  • Werner Schurr
  • Jurgen Zapf
  • E. Rudolf Froesch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 293)


Two major forms of insulin-like growth factors (IGF-I and IGF-II) and their specific binding proteins have been detected in body fluids, including serum, cerebrospinal fluid, breast milk, lymph, and saliva. Extracts of almost any tissue reveal the presence of IGFs. Many cells in culture secret IGFs and various forms of their carrier proteins into the medium (1–3).


Growth Hormone Growth Hormone Secretion Specific Binding Protein Dawn Phenomenon Snell Dwarf Mouse 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hans-Peter Guler
    • 2
  • Katharina Wettstein
    • 1
  • Werner Schurr
    • 3
  • Jurgen Zapf
    • 1
  • E. Rudolf Froesch
    • 1
  1. 1.Metabolic Unit, Department of MedicineUniversity HospitalZurichSwitzerland
  2. 2.Ciba-Geigy Corp.SummitUSA
  3. 3.Ciba-Geigy AGBasleSwitzerland

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